Canaglu (canagliflozin) is an SGLT2 inhibitor antidiabetic drug, usually taken once daily. The timing is flexible, but missed dose management and dosage adjustment principles require attention.

1. Once Daily, Taken on an Empty Stomach or With Food

1. Timing

Take once daily, preferably at a fixed time to maintain stable blood drug concentrations.

It may be taken on an empty stomach or with food; administration is not affected by meals.

If taken with food, it may reduce the possibility of stomach discomfort.

2. Administration Method

Swallow the tablet whole; do not chew, crush, or break it.

Take with an appropriate amount of warm water.

Maintain adequate hydration during treatment to avoid dehydration.

3. Population Precautions

Elderly patients and those with renal impairment should use it after physician assessment.

When used with insulin or sulfonylureas, watch for the risk of hypoglycemia.

2. Missed Dose Management

1. Take It as Soon as You Remember

If the missed dose is noticed shortly after, take it immediately.

After taking the missed dose, take the next dose at the originally scheduled time.

2. Skip If Close to the Next Dose

If the next dose time is near, skip the missed dose.

Do not take double the dose at once.

Do not increase the dosing frequency on your own.

3. Managing Repeated Missed Doses

If doses are missed repeatedly, inform the physician or pharmacist.

Do not adjust the long-term medication regimen on your own.

Use alarms, pill boxes, or other reminders to help with dosing.

3. Dosage Adjustment Principles

1. Starting Dose

Usually determined by the physician based on blood glucose levels, renal function, and concomitant medications.

Do not decide the starting dose on your own.

2. Basis for Adjustment

Adjust based on blood glucose control, changes in renal function, and tolerability.

If renal function declines, dose reduction or discontinuation may be needed.

If recurrent hypoglycemia occurs, the dose should be reassessed.

3. Precautions During Adjustment

Dosage adjustment must be made under physician guidance.

Do not increase the dose on your own because of a missed dose.

During adjustment, strengthen blood glucose monitoring, record changes, and provide feedback at follow-up visits.