Canaglu(canagliflozin)belongs to SGLT2 inhibitors,and its action depends on the renal glucose excretion mechanism.Therefore,it is contraindicated or should be used with caution in certain populations,and a clear assessment must be made before use.

I.Patients with Type 1 Diabetes Mellitus

1.Reasons for Contraindication

This product is not suitable for glycemic control in patients with type 1 diabetes mellitus.

Type 1 diabetes mellitus depends on insulin therapy,and the mechanism of action of this product does not match.

It may increase the risk of ketoacidosis.

2.Risk Reminders

Ketoacidosis may occur even when blood glucose is normal or mildly elevated.

Seek emergency medical attention if nausea,vomiting,abdominal pain,fatigue,or deep rapid breathing occurs.

This product must not be used as a substitute for insulin.

3.Medication Principles

This product is contraindicated in patients with type 1 diabetes mellitus.

If taken accidentally,seek medical evaluation immediately.

Treatment must be formulated by an endocrinology specialist.

II.Patients with Severe Renal Impairment

1.Reasons for Contraindication

The glucose-lowering effect of this product depends on renal function,and efficacy decreases when renal function is severely reduced.

Drug excretion is affected,and the risk of adverse reactions increases.

It is contraindicated in patients with severe renal impairment.

2.Risk Reminders

It may worsen renal impairment.

The risk of urinary tract infections,dehydration,and electrolyte disturbances increases.

Renal function should be monitored regularly during medication.

3.Medication Principles

Glomerular filtration rate must be assessed before medication.

If renal function declines,follow up promptly and discontinue the drug if necessary.

Do not adjust the dose on your own.

III.Dialysis Patients

1.Reasons for Contraindication

Dialysis patients have basically lost renal function,and this product is unlikely to exert a glucose-lowering effect.

Drug metabolism and excretion pathways are limited,and the risk increases significantly.

This product is contraindicated in dialysis patients.

2.Risk Reminders

It may cause fluid imbalance,hypotension,and infection.

Combined with dialysis treatment,it may increase the burden on the body.

Seek medical attention immediately if discomfort occurs.

3.Medication Principles

Dialysis patients must not use this product.

Blood glucose management should be switched to an appropriate alternative regimen by a specialist.

Any medication adjustment must follow medical advice.