Tamoxifen is a synthetic antiestrogenic drug with a structure similar to estrogen. It can compete with estradiol for estrogen receptors, form stable complexes with estrogen receptors, and be transported into the nucleus.

1、 Drug name

1. Product Name: Nolvadex ®、 Nolvadex ® D

2. Common name: Tamoxifen

2、 Indications

1. Treat breast cancer.

2. Treating infertility caused by ovulation disorders.

3. Reduce the risk of breast cancer in high-risk women.

3、 Specifications and characteristics

Nolvadex D20mg: Octagonal white film coated tablet, with one side labeled "Nolvadex D"

4、 Main components

Active ingredient: Tamoxifen citrate

5、 Usage and dosage

1. Breast cancer treatment: the recommended dose is 20mg/day.

2. Infertility treatment:

Menstrual regularity: Take 20mg daily from the 2nd to the 5th day of the menstrual period.

When the effect is not satisfactory, it can be increased to 40mg or 80mg per day.

Irregular menstruation: Medication can be started on any day.

Breast cancer risk reduction: 20mg/day, lasting for 5 years.

6、 Dose adjustment

1. Omission treatment: Take the medication immediately when remembered, and skip if it is close to the next medication time.

2. Double dose supplementation is prohibited.

7、 Medication precautions

1. Medication time: Not specified before or after meals.

2. Leakage treatment: Adjust the dosage according to the above principles.

3. Overtreatment: Immediately consult a doctor or pharmacist.

4. Before the surgery, it is necessary to inform the doctor of the medication situation.

8、 Medication for special populations

1. Pregnant women: Prohibited, pregnancy should be avoided within 9 months after discontinuation of medication.

2. Breastfeeding period: Consult a doctor before medication.

3. Children: Not applicable.

4. Driving effects: May cause fatigue, caution should be exercised when symptoms persist.

9、 Adverse reactions

1. Serious adverse reactions:

Thrombotic symptoms (leg swelling, chest pain, difficulty breathing).

Symptoms of stroke (limb weakness, speech difficulties).

Severe skin reaction (Stevens Johnson syndrome).

Risk of uterine cancer.

2. Common adverse reactions:

Hot flashes, rash, nausea, fatigue.

Vaginal secretions and irregular menstruation.

Changes in vision and abnormal liver function.

10、 Contraindications

1. Pregnant women or those who may become pregnant.

2. Allergic to tamoxifen or any ingredients.

3. I am currently using anastrozole or undergoing infertility treatment.

4. History of thrombosis or family history.

5. Simultaneously using anticoagulant drugs such as warfarin.

11、 Drug interactions

1. Oral contraceptives and hormone replacement therapy.

2. Antidepressants (paroxetine, fluoxetine).

3. Anticoagulants (warfarin).

4. Antibiotics (erythromycin, clarithromycin).

5. Aromatase inhibitors (anastrozole, letrozole).

12、 Storage method

1. Storage temperature: not exceeding 30 ℃.

2. Keep the original packaging away from light and moisture.

3. Placed out of reach of children

13、 Special Reminder

1. Non hormonal contraception should be used during treatment and for 9 months after discontinuation of medication.

2. Doctors should assess the risk of breast cancer before taking the medicine.

3. If any adverse reactions occur, seek medical attention promptly.

4. Lactose intolerant individuals should be aware that medications contain lactose components.

Tamoxifeninformation