Nicergoline increases cerebral arterial blood flow and improves energy metabolism in the brain through its alpha receptor blocking effect and direct soothing effect on vascular smooth muscle.

1、 Drug name

1. Common name: Nicergoline

2. Product Name: SERMION ® (サブミオン)

3. Dosage form: Tablets (5mg)

2、 Indications

Improvement of chronic cerebral circulation disorders associated with post-stroke sequelae, such as decreased motivation and lack of interest.

3、 Specifications and characteristics

Tablets: White film coated tablets, diameter 6.2mm, thickness 3.0mm, each containing 5mg of nicergoline.

4、 Main components

Each tablet contains 5mg of nicergoline.

5、 Usage and dosage

1. Adult dosage: 15mg per day, divided into 3 oral doses (5mg each time, equivalent to 1 tablet or 0.5g powder).

2. Adjustments can be made according to age and symptoms.

6、 Dose adjustment

1. Elderly patients: Due to possible decline in physiological function, it is recommended to reduce usage.

2. Children: There is no clinical research data yet, and safety has not been established.

7、 Medication precautions

1. Before and after meals: Unless otherwise specified, it can be taken with meals or on an empty stomach as usual.

2. Missing dose: If missed once, it should be replenished as soon as possible; If it is close to the next medication time, skip the missed dose and do not double the dosage.

3. Vomiting: If vomiting occurs shortly after taking medication, it is recommended to consult a doctor to see if additional medication is needed.

4. Medication method: PTP packaged drugs should be taken out of the aluminum foil plate to avoid swallowing the aluminum foil and causing esophageal damage.

8、 Medication for special populations

1. Pregnant women: Use only when the benefits outweigh the risks, animal experiments have shown that it may affect fetal development.

2. Breastfeeding women: It is necessary to balance the benefits of treatment and breastfeeding, as animal experiments have shown that drugs can enter breast milk.

3. Children: No relevant clinical data available, not recommended for use.

4. Elderly people: It is recommended to reduce the amount and closely monitor.

9、 Adverse reactions

Occurrence rate 0.1% -1% or frequency unknown:

1. Digestive system: loss of appetite, nausea, diarrhea, constipation, abdominal pain, dry mouth.

2. Liver: Liver dysfunction.

3. Circulating system: palpitations, dizziness, standing dizziness, hot flashes.

4. Nervous system: drowsiness, fatigue, headache, tinnitus, insomnia.

5. Allergies: rash, itching, urticaria.

10、 Contraindications

Patients with incomplete hemostasis after intracranial hemorrhage (which may worsen the bleeding).

11、 Drug interactions

It is not explicitly listed, but the doctor should be informed of all medications being used before use.

12、 Storage method

1. Tablets: Store at room temperature.

2. Validity period: 3 years.

13、 Manufacturer

1. Manufacturer and seller: Tanabe Pharma Co., Ltd

2. Address: 3-2-10 Daoxiu cho, Chuo ku, Osaka City, Japan

Nicergolineinformation