Raloxifene is a SERM drug with both bone protection and breast cancer risk reduction. It is mainly used for postmenopausal women, with good tissue selectivity and safety. It is one of the important treatment options for risk management of osteoporosis combined with breast cancer.

1、 Drug name

1. Common name: Raloxifene Hydrochloride

2. Product Name: EVISTA ®

2、 Indications

1. Treatment and prevention of osteoporosis in postmenopausal women.

2. Reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis.

3. Reduce the risk of invasive breast cancer in postmenopausal women with a high risk of invasive breast cancer.

4. Important limitation: It is not used to treat invasive breast cancer, reduce the risk of recurrence of breast cancer or reduce the risk of non invasive breast cancer.

3、 Specifications

60mg/tablet.

4、 Main components

Active ingredient: Raloxifene hydrochloride.

5、 Usage and dosage

1. Recommended dosage: Take 60mg orally once a day.

2. Medication time: It can be taken at any time of the day and is not affected by meals.

3. The optimal course of treatment for invasive breast cancer risk is unclear.

6、 Dose adjustment

1. Elderly patients do not need to adjust their dosage.

2. Patients with mild to moderate renal dysfunction should use with caution, while patients with moderate to severe renal and liver dysfunction should use with caution. There is currently no clear dosage adjustment guideline, and it is recommended to use under close monitoring by a doctor.

7、 Medication precautions

1. Before and after meals: can be taken with meals or on an empty stomach, food has no clinical significance in affecting absorption.

2. Missed medication: If you miss the medication time, you should take it as soon as possible; If it is close to the next medication time, skip the missed dose and take the next dose at the regular time. Do not take double the dose at once.

3. Vomiting: If vomiting occurs after taking medication, it is not recommended to take it again. The medication should be taken at the next regular time according to the original plan.

4. Long term bed rest/travel: Medication should be discontinued at least 72 hours before planning for prolonged bed rest (such as postoperative recovery) or long-distance travel, and resumed after complete recovery of activity or completion of travel.

5. Supplements: During the treatment or prevention of osteoporosis, if the daily dietary intake is insufficient, calcium supplements and vitamin D should be supplemented (recommended daily calcium intake is about 1500mg, vitamin D is 400-800IU).

8、 Medication for special populations

1. Pregnant women: Prohibited, may cause harm to the fetus.

2. Breastfeeding period: Not recommended for use, safety unknown.

3. Children: Safety and effectiveness have not yet been established.

4. Elderly people (≥ 65 years old): No need to adjust dosage.

5. Individuals with liver and kidney dysfunction: use with caution, especially those with moderate to severe injuries.

9、 Adverse reactions

1. Common (>2% and more than placebo): hot flashes, leg cramps, peripheral edema, flu like symptoms, joint pain, and excessive sweating.

2. Serious adverse reactions: venous thromboembolism (deep vein thrombosis, pulmonary embolism, retinal vein thrombosis), increased risk of stroke mortality.

3. Other: nausea, headache, rash, etc.

10、 Contraindications

1. Individuals who are active or have a history of venous thromboembolism.

2. Pregnant women.

3. Individuals known to be allergic to any ingredient of this product.

11、 Drug interactions

1. Kolacetamide: Do not use in combination as it significantly reduces the absorption of raloxifene.

2. Warfarin: When used in combination, the prothrombin time should be closely monitored.

3. High protein binding drugs (such as diazepam, diltiazem, lidocaine): caution should be exercised when using them together.

4. Systemic estrogen: Not recommended for combination.

5. Safely compatible drugs: amoxicillin, antacids, corticosteroids, digoxin, etc.

12、 Storage method

1. Store at room temperature between 20 ° C and 25 ° C (68 ° F and 77 ° F), and allow for short periods of time between 15 ° C and 30 ° C (59 ° F and 86 ° F).

2. Avoid light and moisture, and keep out of reach of children.

Raloxifeneinformation