Leboresen is a novel dual orexin receptor antagonist developed and produced by Eisai, a Japanese company, specifically designed to treat insomnia characterized by difficulty falling asleep or maintaining sleep.

1、 Indications

DAYVIGO is an appetite suppressant used to treat adult insomnia, characterized by difficulty falling asleep and/or sleep maintenance disorders.

2、 Usage and dosage

Recommended dosage: The initial dose is 5mg, taken once before bedtime every night, ensuring at least 7 hours of sleep after taking the medication. According to clinical response and tolerability, the maximum recommended dose can be increased to 10mg.

Dose adjustment:

Liver dysfunction: The maximum dose for patients with moderate liver injury is 5mg/day; Patients with severe liver injury are prohibited from using it.

Drug interactions: Avoid combination with strong/medium acting CYP3A inhibitors (such as itraconazole, clarithromycin); The maximum dose when combined with weak CYP3A inhibitors (such as ranitidine) is 5mg.

Medication precautions: It can be taken on an empty stomach or after a meal, but eating may delay the onset time. Swallow the entire tablet, no need to replenish if missed.

3、 Side effects

The most common adverse reaction is drowsiness (incidence ≥ 5%, twice as high as placebo). Other side effects that need attention include:

Nervous system: Sleep paralysis (inability to move or speak during wakefulness), hallucinations, and symptoms similar to catastrophizing (temporary leg weakness).

Complex sleep behaviors such as sleepwalking, sleep driving, and unconscious eating require immediate discontinuation of medication.

Mental health risks: exacerbation of depression or suicidal ideation (incidence rate 0.3% -0.4%).

Respiratory depression: Patients with chronic obstructive pulmonary disease (COPD) or moderate to severe sleep apnea should use it with caution.

4、 Medication precautions

Monitoring requirements:

During medication, avoid driving or operating machinery, especially when the dosage exceeds 5mg.

Regularly assess symptoms of depression and abnormal sleep behavior.

Contraindications: Do not use for patients with narcolepsy; The combination of potent CYP3A inducers (such as rifampicin) can reduce efficacy and should be avoided.

Special populations:

Pregnant women: contraception should be used until one month after discontinuation, and the risks should be weighed when using it during pregnancy.

Breastfeeding period: Medications may be secreted through breast milk, it is recommended to suspend breastfeeding.

Elderly: Patients aged 65 and above who use a dose of 10mg have an increased risk of drowsiness, and it is recommended to start with 5mg.

5、 Storage method

Store in a dark place at 20-25 ° C (15-30 ° C is allowed for a short period of time) and keep out of reach of children.

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