All Names:
Indications:
Manufacturer:LUCIUS PHARMACEUTICAL (LAOS) CO., LTD
Customs Clearance Procedure:If the customs requires the package for customs clearance, please pay the customs clearance fee according to the content of EMS SMS and customs regulations.
Stiripentol is a novel antiepileptic drug specifically designed to treat rare and severe epilepsy.
Drug name
Common name: Stiripentol
Product Name: DIACOMIT ®
indication
Used for treatment:
Dravet syndrome patients aged 2 years and above: need to use in combination with clobazam
Not recommended: as a monotherapy for Dravet syndrome
Specifications and characteristics
Capsules:
250mg: Pink, printed with "Diacomit" and "250mg"
500mg: white, printed with "Diacomit" and "500mg"
Oral suspension powder:
250mg/pack: light pink fruit flavored powder
500mg/pack: light pink fruit flavored powder
main ingredients
Active ingredient: Streptopentanol
Accessories:
Capsules: gelatin, magnesium stearate, polyvinylpyrrolidone, etc
Suspension agents: Aspartame, Sodium Carboxymethylcellulose, Glucose, etc
Usage and Dosage
Recommended dosage: 50mg/kg/day, taken in 2-3 doses
Maximum dose: 3000mg/day
Medication requirements:
Capsules: Take whole capsule with meals, do not break or chew
Suspension: Take immediately after mixing 100mL of water with meals
Missed medication: Take it as soon as possible, skip if it is close to the next medication time
Vomiting: No need for supplementation
Dose adjustment
Sleepiness: Consider reducing the dose of chlorpromazine by 25%
Diarrhea:
Level 3 no anti diarrhea treatment: pause until the original dose is restored and continue
Level 3 anti diarrhea treatment: pause until reduced after recovery
Level 4: Permanent discontinuation of medication
Hepatotoxicity:
Elevated level 2 bilirubin: pause until recovery and continue with the original dose
Level 3 ALT/AST or bilirubin elevation: pause until reduced after recovery
Level 4: Permanent discontinuation of medication
Medication precautions
Diet: Must be taken with meals
Monitoring requirements:
Blood routine examination before treatment and every 6 months
Regular monitoring of weight gain (children)
Beware of suicidal tendencies
Taboo:
Avoid alcohol
Suspension containing phenylalanine should be used with caution in patients with phenylketonuria
Medication for special populations
Pregnancy/lactation:
Pregnancy: May cause malformations, contraception is necessary during treatment and after discontinuation of medication
Breastfeeding: Not recommended
Children: Safe and effective for patients aged ≥ 2 years old
Liver dysfunction: moderate to severe requiring reduction in dosage
Renal insufficiency: Not recommended for moderate to severe cases
adverse reaction
Common (≥ 10%):
Sleepiness (67%), decreased appetite (45%), ataxia (27%), weight loss (27%), low muscle tone (24%), nausea (15%), tremor (15%)
Serious:
Neutropenia (13%), thrombocytopenia (13%), suicidal tendencies
contraindication
No absolute contraindications
Drug interactions
Chlorpromazine: Increase its blood concentration and reduce it
CYP3A4/CYP2C19 substrates: may require reduction
CYP1A2/CYP3A4/CYP2C19 Strong Inducing Agents: Avoid Combination Use
Storage method
Store at 20-25 ° C, keep away from light in original packaging
Take the suspension immediately after preparation
Diacomitinformation