Fumarate propafenone tablets (Vemlidy) are nucleoside analogue reverse transcriptase inhibitors (NRTI) that inhibit the reverse transcriptase activity of hepatitis B virus (HBV), block the extension of viral DNA strands, and thus inhibit viral replication.

Drug name

Common name: Tenofovir Alafenamide Fumarate Tablets

Product Name: Vemlidy ®

Other names: TAF

indication

Used to treat adult chronic hepatitis B virus (HBV) infection with compensatory liver disease.

Specifications and characteristics

25mg/tablet, yellow circular film coated tablet, with "GSI" engraved on one side and "25" engraved on the other side.

main ingredients

Active ingredient: Propenoltenofovir (equivalent to 28mg fumarate)

Accessories: cross-linked carboxymethyl cellulose sodium, lactose monohydrate, etc

Usage and Dosage

Standard dose: 25mg once daily, taken with meals

Usage: Swallow the whole tablet, do not break or chew it

Dose adjustment

1. Missed medication: Take it immediately upon discovery, and skip if it is close to the next medication time

2. Renal insufficiency: creatinine clearance rate ≥ 15mL/min does not require adjustment, and is not recommended for end-stage renal disease (<15mL/min)

3. Liver dysfunction: Child Pugh grade A does not require adjustment, and is not recommended for decompensated stage (B/C grade)

Medication precautions

1. Pre medication testing: HIV infection screening is necessary, and HIV infected individuals need to undergo combined antiviral therapy

2. Monitoring requirements:

-Regularly check renal function (creatinine, blood phosphorus, etc.) before and during medication

-Continuous monitoring of liver function is required for several months after drug withdrawal (may cause acute exacerbation of hepatitis B)

3. Special Warning:

-Be alert to lactic acidosis/hepatic steatosis (manifested as fatigue, difficulty breathing, etc.)

-Avoid using in combination with potent P-gp inducers such as rifampicin and St. John's wort

Medication for special populations

Pregnant women: need to weigh the pros and cons (pregnancy registration number 1-800-258-4263)

Breastfeeding period: Safety unknown, it is recommended to suspend breastfeeding

Children: Safety has not been established for those under 18 years old

Elderly: No need to adjust dosage, but kidney function needs to be monitored

adverse reaction

Common (≥ 5%): headache, abdominal pain, fatigue, cough, nausea, back pain

Serious adverse reactions: lactic acid poisoning, acute aggravation of hepatitis B, renal function damage

contraindication

No absolute contraindications, but contraindicated for patients with end-stage renal disease and decompensated cirrhosis

Drug interactions

1. Taboo combination: Strong P-gp inducers (such as carbamazepine, rifampicin)

2. Use drugs with caution: nephrotoxic drugs (such as NSAIDs, aminoglycosides)

3. Safe combination: No significant interaction was observed between sofosbuvir/vapatavir, etc

Storage method

1. Temperature: Below 30 ° C (86 ° F)

2. Packaging: Keep the original packaging sealed and avoid light exposure

3. Deadline: Pay attention to checking the validity period

Vemlidyinformation