Trelagliptin, as a long-acting DPP-4 inhibitor, has the characteristics of both fixed and flexible medication time. It is necessary to arrange the medication time reasonably based on the drug characteristics and individual patient conditions.

1. Routine medication duration

(1) Basic plan: It is recommended to take it orally once a week at a fixed time, and you can choose any morning or evening of the week.

(2) Time selection: It is recommended to prioritize choosing the same day and time slot every week (such as before breakfast every Monday) to establish a regular medication habit.

2 Dietary associations

(1) Before and after meals: Medication is not affected by eating and can be taken within 30 minutes before or 2 hours after meals.

(2) Fasting requirement: There is no need to strictly fast, but avoid taking it with high-fat meals as it may affect absorption rate.

3 Special circumstances adjustment

(1) Omission treatment: If you forget to take your medication, you should immediately take it when you remember; If it is close to the next medication time (<3 days), skip that dose.

(2) Time difference response: When traveling internationally, maintain the medication cycle at the original place of residence, or adjust to the time zone closest to the original interval of 7 days according to the new time zone.

4. Timing of Combination Medication

(1) When combined with other hypoglycemic drugs, it is recommended to take them separately to avoid gastrointestinal discomfort.

(2) When combined with diuretics and other drugs that may affect blood sugar, it is recommended to take them at intervals of at least 2 hours.