The standard dose of Gilteritinib is 120mg orally once daily, usually taken as a single 120mg tablet on an empty stomach. The specific dosage may be adjusted according to the patient's condition.

1 standard dose

(1) Adult patients: The recommended dosage is 120mg per day, taken in whole tablets, avoid taking with food (2 hours before or 1 hour after meals).

(2) Treatment cycle: Continue medication until disease progression or intolerable toxic reactions occur.

2. Routine administration methods

(1) Standard dose: Take 120mg orally once daily, usually corresponding to one 120mg tablet.

(2) Dosage: It is recommended to take on an empty stomach (2 hours before or 1 hour after meals).

3 Dosage adjustment situation

(1) First reduction: from 120mg/day (1 tablet) to 80mg/day (may require taking 2 40mg tablets).

(2) Second reduction: from 80mg/day to 40mg/day (1 40mg tablet).

(3) When unable to tolerate 40mg/day, the medication should be permanently discontinued.

4 Special population doses

(1) Liver dysfunction: Moderate injury (Child Pugh B grade) should be reduced to 80mg/day, and severe injury (Child Pugh C grade) should be avoided.

(2) Renal insufficiency: Mild to moderate injury does not require adjustment, and there is insufficient data on patients with end-stage renal disease.

(3) Elderly patients: No routine adjustments are needed, but monitoring needs to be strengthened.

5 situations where dosage needs to be adjusted

(1) Differentiation syndrome: If symptoms appear, medication should be immediately suspended and reduced before recovery.

(2) QT interval prolongation: Discontinue medication when>500ms and reduce dosage after recovery.

(3) Pancreatitis: Discontinue treatment when amylase/lipase>2-fold ULN.

6 Special precautions

(1) Swallow whole tablet: Do not break, crush or chew the tablet.

(2) Omission treatment: If missed, it should be taken immediately when remembered, but if it is less than 12 hours before the next medication, it should be skipped.

(3) Vomiting treatment: Vomiting after taking medication should not be supplemented, and the next medication should be taken according to the original plan.