It is recommended to take Capivasortib with food to improve the stability and bioavailability of drug absorption. The specific medication plan needs to be adjusted according to individual circumstances and doctor guidance, while also paying attention to the handling of missed doses and medication precautions for special populations.

1. Regular administration time

(1) It is recommended to take it with food to improve the stability and bioavailability of drug absorption.

(2) Avoid taking on an empty stomach to reduce the risk of gastrointestinal adverse reactions.

2. Specific medication plan

(1) Standard dose: usually twice a day, 400mg each time, with an interval of about 12 hours.

(2) Treatment schedule: Take continuously for 4 days, stop taking for 3 days, and cycle once a week.

3. Handling of missed services

(1) If it is more than 6 hours before the next administration, it can be taken immediately.

(2) If it is less than 6 hours, skip this dose and take the next dose according to the original plan.

4. Special precautions

(1) Avoid taking with grapefruit or grapefruit juice as it may affect drug metabolism.

(2) Regular monitoring of liver function, blood glucose, and electrolyte levels is required during medication.

5. Medication for special populations

(1) Patients with liver dysfunction: moderate to severe liver dysfunction requires dose adjustment.

(2) Patients with renal insufficiency: Mild to moderate damage does not require adjustment, while severe damage requires caution.

6. Requirements for liver function monitoring

(1) May cause drug-induced liver injury, baseline liver function testing is required before treatment

(2) When ALT/AST exceeds 3 times the normal value, medication should be suspended

(3) Bilirubin>2 times normal value requires permanent discontinuation of medication

7. Drug interactions

(1) Avoid using strong CYP3A4 inducers/inhibitors in combination

(2) Combination with proton pump inhibitors may reduce bioavailability

(3) Take calcium/magnesium/aluminum containing preparations every 2 hours