The side effects of Capivasertib mainly include digestive system reactions, skin reactions, metabolic abnormalities, etc., most of which can be relieved through symptomatic treatment. Serious side effects require timely medical attention, and relevant indicators should be regularly monitored and preventive measures taken during medication.

1. Common side effects and mitigation methods

(1) Digestive system reactions: such as nausea, diarrhea, and decreased appetite. It is recommended to eat in small portions, avoid greasy foods, and use antiemetic or antidiarrheal medication if necessary.

(2) Skin reactions: including rash and itching. Keep the skin clean and moist, avoid irritating skincare products, and in severe cases, use local or oral antihistamines.

(3) Fatigue: Reasonably arrange rest and activities, ensure sufficient sleep, and avoid overexertion.

2. Serious side effects to be wary of

(1) Abnormal liver function: manifested as jaundice, clay stool, etc. During medication, regular monitoring of liver enzymes is necessary to avoid alcohol consumption and hepatotoxic drugs.

(2) High blood sugar: excessive drinking, frequent urination, and thirst. Monitor blood sugar levels, adjust diet structure, and use hypoglycemic drugs if necessary.

(3) Arrhythmia: palpitations, dizziness. Avoid caffeine intake and undergo regular electrocardiogram checks.

3. Precautions for special populations

(1) Elderly patients are more prone to dehydration and electrolyte imbalance, and need to strengthen monitoring of kidney function and electrolytes.

(2) Patients with liver and kidney dysfunction: The dosage should be adjusted according to the degree of damage, and the risk of drug accumulation should be closely monitored.

4. Preventive measures

(1) Conduct a comprehensive assessment of underlying diseases before medication, and complete baseline examinations such as blood routine and liver and kidney function.

(2) Avoid co administration with potent CYP3A4 inhibitors or inducers to prevent drug interactions.

(3) Maintain sufficient water intake and a balanced diet during treatment.