Tartirelin is a thyroid stimulating hormone releasing hormone analog mainly used for the treatment of spinal cord cerebellar degeneration. Its side effects involve multiple systems and can be alleviated through targeted measures.

1. Common side effects

(1) The nervous system

Dizziness (about 12%), headache (8%), and tremors (5%) may occur, usually dose related. It is recommended to gradually increase the initial low dose.

(2) Digestive system

About 15% of patients experience nausea and vomiting, and it is recommended to take it after meals; The incidence of diarrhea is about 7%, and attention should be paid to fluid replacement.

(3) Cardiovascular system

May cause palpitations (3%) or blood pressure fluctuations, it is recommended to rest in a supine position for 30 minutes after the first medication.

2. Mitigation measures

(1) Neurological response

Dizziness patients should avoid sudden changes in body position; When severe tremors occur, beta blockers can be considered as adjuvant therapy.

(2) Gastrointestinal discomfort

Continuous nausea can be treated in combination with domperidone; When experiencing diarrhea, it is recommended to use adsorbents such as montmorillonite powder to maintain electrolyte balance.

(3) Cardiovascular management

Regularly monitor blood pressure and heart rate, and evaluate the necessity of adjusting medication dosage when significant fluctuations occur.

3. Special precautions

(1) Thyroid function

May interfere with thyroid hormone level testing, regular follow-up of TSH and free thyroxine is required during medication.

(2) Drug interactions

Combined use with central nervous system inhibitors may enhance sedative effects, and caution should be exercised before driving or operating machinery.

(3) Long term use

After more than 6 months of treatment, the efficacy risk ratio should be evaluated, and attention should be paid to observing the balance between improvement in motor function and side effects.