Rilute tablets are specific drugs for the treatment of amyotrophic lateral sclerosis (ALS), and special attention should be paid to liver function monitoring and medication management for special populations. The following provides a detailed explanation from two aspects: indications and medication precautions.

1. Indications

Used for the treatment of amyotrophic lateral sclerosis (ALS), the US FDA has designated it as an orphan drug for this purpose.

2. Medication precautions

(1) Liver function monitoring

Three months before treatment, transaminase should be monitored monthly, and medication should be stopped immediately if bilirubin levels rise. Individuals with baseline transaminase levels exceeding 5 times the normal range are prohibited from using it.

(2) Hematological system reaction

Neutropenia (<500/mm ³) may occur in the first 2 months, and patients with fever should report it promptly.

(3) Interstitial lung disease

When interstitial lung diseases such as allergic pneumonia occur, medication should be stopped immediately.

(4) Medication for special populations

During pregnancy, it is necessary to assess fetal risks and avoid use during lactation. Elderly patients may be more sensitive, and those with liver dysfunction need to adjust their dosage.

(5) Handling of missed services

Take the missed dose as soon as possible and skip it when it is close to the next medication. Double dose supplementation is prohibited.