As a medication for treating amyotrophic lateral sclerosis (ALS), the side effects of Rilute tablets can be divided into severe reactions that require immediate medical attention and mild symptoms that can be self relieved. Reasonable monitoring and preventive measures can effectively reduce medication risks. The following provides a detailed explanation from two aspects: classification of side effects and mitigation methods.

1. Serious side effects requiring immediate medical attention

(1) Liver toxicity manifestations

When symptoms such as abdominal pain, lighter stool color, darker urine color, decreased appetite, yellowing of eyes or skin appear, it suggests the possibility of liver damage and requires immediate discontinuation of medication and medical attention.

(2) Abnormal blood system

Symptoms of infection such as fever, chills, cough, painful or difficult urination may be caused by decreased white blood cells and require emergency medical intervention.

(3) Neurological response

Central nervous system symptoms such as confusion, seizures, hallucinations, or pulmonary complications such as severe breathing difficulties require immediate treatment.

2. Mild side effects that can be self relieved

(1) Feeling abnormal

Peripheral nerve symptoms such as burning, numbness, and stabbing pain are usually mild, and continuous medication may gradually adapt.

(2) Gastrointestinal discomfort

Dry mouth, bloating, and satiety can be relieved by adjusting diet (such as eating small meals frequently). If they continue to worsen, consult a doctor.

(3) Systemic symptoms

It is recommended to avoid driving or operating machinery due to fatigue, dizziness, and drowsiness, as most of them alleviate with prolonged medication time.

3. Side effect mitigation and preventive measures

(1) Regular monitoring

Regularly check liver function and blood routine according to medical advice. Patients of Japanese descent may need to adjust their dosage to reduce risk.

(2) Drug interaction management

Avoid using CYP1A2 inhibitors (such as fluvoxamine) or inducers in combination to prevent reduced efficacy or increased toxicity.

(3) Lifestyle adjustment

Maintain sufficient water intake to reduce the burden on the kidneys, and seek medical evaluation promptly in case of rapid weight gain or rash.