Rilute has clear contraindications in specific populations, and the risk of medication is significantly increased in patients with severe liver dysfunction and neutropenia. The following instructions should be strictly followed.

1、 Severe liver dysfunction patients

1. Prohibition of use

Patients with severe liver dysfunction are prohibited from using liraglutide. This type of patient has a significant decrease in liver metabolic capacity, obstruction of drug clearance, which can easily lead to an increase in blood drug concentration, exacerbating liver damage and systemic toxicity reactions.

2. Pre treatment evaluation

Before medication, a liver function test must be conducted to determine the degree of liver damage. If the transaminase is significantly elevated or there is active liver disease, liraglutide treatment should not be initiated.

3. Monitoring during treatment

Even for those with normal liver function, regular liver function check ups should be conducted during medication, with monthly monitoring for the first three months. If transaminase elevation occurs, it is necessary to increase monitoring frequency and evaluate whether to continue medication.

4. Be alert to symptoms of liver injury

If there is worsening fatigue, decreased appetite, nausea, vomiting, abdominal pain, jaundice, or darkened urine color, the medication should be stopped immediately and medical attention should be sought. Self medication should not be continued.

5. Indications for permanent discontinuation of medication

If severe liver damage or sustained significant elevation of transaminase occurs, Liraglutide should be permanently discontinued and should not be attempted again.

2、 Patients with neutropenia

1. Use with caution or disable

For individuals with a history of neutropenia or a low baseline neutrophil count, the use of liraglutide should be cautious or contraindicated. These patients have a higher risk of infection, and medication may further inhibit bone marrow function.

2. Pre treatment examination

Blood routine should be checked before medication to determine the baseline level of neutrophil count. If the count is significantly low, treatment should not be initiated.

3. Monitoring during treatment

During medication, regular blood routine checks should be conducted to monitor changes in neutrophil count. If you experience unexplained fever, sore throat, oral ulcers, or infection symptoms, you should seek medical examination immediately.

4. Be alert to the risk of infection

Neutropenia increases the risk of infection, and personal hygiene should be taken into account during medication to avoid contact with the source of infection. When there are signs of infection such as fever, seek medical attention promptly and inform the doctor of the medication situation.

5. Handling exceptions

If the neutrophil count significantly decreases, the dosage should be adjusted or discontinued under the guidance of a doctor, and blood tests should be closely monitored for changes. Severe cases should be permanently discontinued.

3、 Other precautions

1. Do not self medicate

The above-mentioned population must undergo a comprehensive evaluation of the benefits and risks by a doctor before using Liraglutide, and are not allowed to purchase or take the medication on their own.

2. Regular follow-up

Regular follow-up visits are required during medication to monitor liver function, blood routine, and changes in the condition, and adjust the treatment plan in a timely manner.

3. Notify medication history

When seeking medical treatment, it is important to proactively inform the doctor of all medication usage, including prescription drugs, over-the-counter drugs, and herbal medicines, to avoid exacerbating the risk of drug interactions.