Rilute tablets are a drug used to treat amyotrophic lateral sclerosis (ALS), developed by the French company Sanofi.

1、 Drug name

Common name: Liraglutide tablets

Product Name: Rilute

2、 Indications

Used for treating amyotrophic lateral sclerosis (ALS).

3、 Specifications and characteristics

Specification: 50mg film coated tablets.

Appearance: White capsule shaped tablet with the words "RPR202" engraved on one side.

4、 Main components

Active ingredient: Liraglutide (2-amino-6- (trifluoromethoxy) benzothiazole).

5、 Usage and dosage

Recommended dosage: 50mg orally, twice daily.

Medication time: Take at least 1 hour before meals or at least 2 hours after meals.

6、 Dose adjustment

Patients with mild or moderate liver dysfunction may need to adjust their dosage.

Patients with baseline serum transaminase levels exceeding 5 times the upper limit of normal are not recommended to use it.

7、 Medication precautions

It must be taken on an empty stomach, 1 hour before or 2 hours after meals.

Serum transaminase levels should be monitored before and during treatment.

If there is evidence of liver dysfunction, the medication should be discontinued.

When missed, the dose should be skipped and should not be doubled.

If vomiting occurs after taking medication, it is not recommended to take it again.

8、 Medication for special populations

Pregnant women: Based on animal data, it may cause harm to the fetus.

Breastfeeding period: It is unclear whether it is secreted through human milk. It is recommended to use it with caution.

Children: Safety and effectiveness have not yet been established.

Elderly patients: No safety differences were observed compared to younger patients.

Liver dysfunction: Patients with mild or moderate liver dysfunction have increased exposure.

9、 Adverse reactions

The most common adverse reactions (incidence ≥ 5% and higher than placebo):

Fatigue, nausea, dizziness, decreased lung function, abdominal pain.

Other adverse reactions include vomiting, joint pain, dry mouth, insomnia, itching, tachycardia, etc.

10、 Contraindications

Patients with a history of severe allergic reactions to liraglutide or any of its ingredients are contraindicated.

11、 Drug interactions

Strong to moderate CYP1A2 inhibitors may increase the risk of adverse reactions.

Strong to moderate CYP1A2 inducers may lead to decreased efficacy.

Co administration with other hepatotoxic drugs may increase the risk of hepatotoxicity.

12、 Storage method

Store at a controlled room temperature of 20 ° C to 25 ° C.

Avoid strong light exposure.

13、 Important safety warning

This product may cause liver damage, neutropenia, interstitial lung disease, and pancreatitis. If patients experience symptoms such as fever, difficulty breathing, and abdominal pain, they should seek medical attention promptly.

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