The usage and dosage of Faropenem should be adjusted according to the type of infection and individual differences in patients. Special attention should be paid to renal function, pregnancy and lactation status, and age factors when using it for special populations. The following is an explanation from three aspects: conventional usage, dosage adjustment, and medication for special populations, to ensure rational use of drugs in clinical practice.

1. Conventional usage and dosage

(1) Adult standard dose: 150-300mg orally, 3 times a day; Severe infections can be increased to 600mg per dose, with a total daily dose not exceeding 1800mg.

(2) Course setting: 5-10 days for respiratory tract infections, 7-14 days for skin and soft tissue infections, and 10-14 days for complex urinary tract infections, which need to be adjusted according to the efficacy.

(3) Usage: It is recommended to take on an empty stomach 1 hour before or 2 hours after meals to avoid consuming high-fat foods that may affect absorption rate.

2. Dose adjustment for special populations

(1) Renal insufficiency: creatinine clearance rate of 30-50mL/min reduced by 50%; Reduce by 75% at a rate of less than 30mL/min, and monitor blood drug concentration if necessary.

(2) Liver dysfunction: mild to moderate damage does not require adjustment; Severe damage (Child Pugh C grade) requires careful use and monitoring of liver function.

(3) Elderly: Patients over 65 years old should adjust their dosage based on kidney function, and it is recommended to reduce the initial dosage by 25% -50%.

3. Precautions for medication for special populations

(1) Pregnancy: Animal experiments have shown embryotoxicity, and human data is limited. It is only used when the benefits to the mother outweigh the risks.

(2) Breastfeeding period: Medications may be secreted into breast milk. It is recommended to suspend breastfeeding during treatment or use alternative medications.

(3) Children: Safety and efficacy have not been established for children under 12 years old, and its use is not recommended; Age 12-18 years old, adjust according to weight based on adult dosage.

(4) Epilepsy patients: Those with a history of central nervous system diseases need to be closely monitored, as beta lactams may lower the seizure threshold.