Amifampridine, as a potassium channel blocker, commonly has side effects involving multiple systems such as the nervous system and digestive system, most of which are mild to moderate, but serious adverse reactions should be noted. The following categories describe their side effects and corresponding measures.

1. Neurological related side effects

The most common type is sensory abnormalities (such as pain around the mouth/limbs), with an incidence rate of about 30% -50%. The incidence of dizziness and headache is about 15% -25%, mostly occurring in the early stages of medication. Attention should be paid to the risk of dose-dependent epileptic seizures, especially in patients with a history of epilepsy.

2 Digestive system reactions

About 20% -35% of patients experience nausea and vomiting, and it is recommended to take it with meals to alleviate symptoms. The incidence of diarrhea is about 10% -15%, usually mild. Occasionally experiencing abdominal pain and indigestion, most of which resolve on their own after 2-4 weeks of treatment.

3 Effects on the cardiovascular system

May cause QT interval prolongation and require regular electrocardiogram monitoring. The incidence of palpitations is about 5% -10%, and hypertensive patients need to strengthen blood pressure monitoring. Elderly patients or those with a history of heart disease are more prone to cardiovascular adverse reactions.

4 Other common adverse reactions

Fatigue (15% -20%) and insomnia (5% -10%) are common systemic symptoms. The incidence of skin reactions such as rash is about 5% -8%, mostly mild. Muscle pain/spasms occur in about 10% of patients and usually do not require discontinuation of medication.

5 Serious Adverse Reaction Warning

The situations that require immediate medical attention include: epileptic seizures, severe allergic reactions (facial swelling/difficulty breathing), persistent severe headaches with vomiting (indicating elevated intracranial pressure), and consciousness disorders. These situations, although rare, require urgent handling.

6 Precautions for Special Groups

Patients with renal insufficiency need to adjust their dosage to prevent accumulation and poisoning. Children taking medication may be more prone to neurological reactions such as behavioral abnormalities. Pregnant women are prohibited from using contraception, and women of childbearing age should take reliable contraceptive measures.