Ibrutinib, while effectively controlling B-cell malignancies, is often accompanied by adverse reactions such as diarrhea, joint pain, and bruising. Most symptoms are mild to moderate, and tolerability can be significantly improved through scientific management; patients need not avoid the drug out of fear, but they must master correct coping methods.

I. Management of Diarrhea

Adjust diet: Choose light, easily digestible foods; avoid spicy, greasy, and high-fiber foods; eat small, frequent meals to reduce intestinal burden.

Replenish fluids: Diarrhea easily leads to dehydration; drink more water or oral rehydration salts to maintain electrolyte balance.

Record bowel movements: Monitor the frequency and character of diarrhea; if it exceeds 4 times per day or is accompanied by fever or bloody stool, seek medical attention promptly.

Pharmacological intervention: For mild cases, antidiarrheal drugs may be used under the guidance of a physician; do not take them long-term on your own.

II. Management of Joint Pain

Moderate activity: Perform gentle joint movements and stretching; avoid prolonged sitting, but avoid strenuous exercise that may worsen pain.

Local heat application: Apply heat to painful areas to relieve stiffness; ensure the temperature is appropriate to prevent burns.

Analgesic medication: When pain is significant, use analgesics such as acetaminophen after physician evaluation; avoid self-use of nonsteroidal anti-inflammatory drugs to prevent increased bleeding risk.

Report promptly: If pain persists and worsens or affects daily activities, inform the physician to evaluate whether dose adjustment is needed.

III. Management of Bruising

Prevent bumps: Pay attention to safety during daily activities; use a soft-bristled toothbrush and an electric razor to reduce skin and mucosal injury.

Observe bruises: Monitor the extent and resolution of bruises; minor bruises usually resolve on their own.

Watch for bleeding signals: If unexplained large bruises, uncontrollable nosebleeds, black stool, or hematuria occur, seek medical attention immediately.

Avoid concomitant use of drugs that increase bleeding: Without physician approval, do not self-administer anticoagulant or antiplatelet drugs such as aspirin or warfarin.