The side effects of Velcade involve multiple aspects such as blood, nervous system, and digestive system, which need to be alleviated through regular monitoring and targeted measures. When taking medication, it is necessary to strictly follow the dosage, contraindications, and precautions for special populations to ensure the safety and effectiveness of treatment.

Common side effects and mitigation methods of bortezomib

1. Hematological system side effects

May lead to thrombocytopenia and neutropenia. Regular monitoring of blood routine is necessary to avoid trauma or strenuous exercise. If there are abnormal bleeding or infection symptoms, seek medical attention immediately.

2. Neurological side effects

Common peripheral neuropathy (numbness/tingling in hands and feet). It is recommended to avoid hot and cold stimulation and wear loose shoes and socks. In severe cases, doctors may adjust the dosage or suspend medication.

3. Digestive system side effects

Including nausea, diarrhea, and decreased appetite. Eat small meals and avoid spicy foods. Doctors may prescribe antiemetic or antidiarrheal medication to assist in relieving symptoms.

4. Fatigue and fatigue

Reasonable rest should be arranged during medication to avoid driving or operating machinery. Moderate activity can help alleviate symptoms, but excessive fatigue should be avoided.

Precautions for the use of bortezomib

1. Dosage and Administration

Strictly follow the doctor's advice when taking medication, and do not adjust the dosage on your own. Injections should be prepared by professionals to avoid tissue damage caused by extravasation.

2. Taboo population

It is contraindicated for individuals allergic to bortezomib or mannitol. Patients with severe liver and kidney dysfunction should use with caution and may require dosage adjustments.

3. Drug interactions

Avoid using strong CYP3A4 inhibitors (such as ketoconazole) or inducers (such as rifampicin) in combination. Chinese herbal medicine may interfere with its efficacy, please consult a doctor before use.

4. Special populations

Pregnant women are prohibited from using contraception, and patients of childbearing age should take reliable contraceptive measures. Breastfeeding should be suspended during lactation. Elderly patients need to be closely monitored for adverse reactions.

5. Emergency response

If there is a severe allergic reaction (difficulty breathing, rash), persistent high fever, or blurred consciousness, the medication should be stopped immediately and medical attention sought. During treatment, it is necessary to carry an emergency contact card with you.