The storage of Velcade requires strict adherence to temperature, light avoidance, and packaging requirements to ensure drug stability and efficacy. The storage conditions may vary depending on the dosage form, and special attention should be paid to the preservation of the original packaging and the expiration date after opening.

Storage method of bortezomib

1. Storage temperature

Unopened bortezomib should be stored in a refrigerator at 2 ° C to 8 ° C to avoid freezing. Before use, it can be briefly stored at room temperature (not exceeding 25 ° C), but must be used up within 24 hours.

2. Light avoidance requirements

Bortezomib should be stored in its original packaging and protected from direct sunlight. The diluted solution should also be stored away from light to prevent drug degradation from affecting the efficacy.

3. Packaging processing

(1) Unopened drugs: Keep the original packaging intact, including the sealing of the outer box and inner packaging.

(2) Refactored solution: If not used immediately, refrigerate (2 ° C to 8 ° C) and ensure sterile operation. Use within 24 hours.

4. Special precautions

(1) Freezing of any dosage form of bortezomib is prohibited as freezing can cause structural damage to the drug.

(2) Keep the medication out of reach of children to prevent accidental ingestion.

(3) Expired or unused drugs should be disposed of through professional medical waste channels.

5. Storage differences of different dosage forms

(1) Freeze dried powder: requires strict refrigeration, and its stability significantly decreases after reconstitution.

(2) Pre filled syringes: also require refrigeration, but may allow for shorter room temperature storage time.

Taboo foods of bortezomib

1. Grapefruit and its products

Grapefruits, grapefruit juice, or related products may inhibit CYP3A4 enzyme activity, increase the blood concentration of bortezomib, and increase the risk of toxicity. During treatment, ingestion should be completely avoided.

2. Seville Orange

Seville orange (bitter orange) and its juice also have CYP3A4 inhibitory effects, which may interfere with drug metabolism. It is recommended to avoid consumption during medication.