PursennidTablets, as a commonly used laxative in Japan, contains sennid glycosides that are effective in treating chronic constipation and preoperative bowel cleansing. However, attention should be paid to the applicable population and course of treatment limitations. The following is a detailed analysis of the effects and precautions from two aspects: chronic constipation treatment and preoperative bowel cleansing application.

1. The therapeutic effect of Japanese PursennidTablets on chronic constipation

(1) Mechanism of action: Fanxie glycoside is metabolized into active substances by the colonic microbiota, directly stimulating the intestinal nerve plexus to enhance peristalsis and improve symptoms of slow transit constipation.

(2) Clinical data: About 80% of patients experience soft stool within 24 hours after medication, and continuous use for 3 days can increase bowel frequency by 2-3 times per week.

(3) Suggested treatment course: The longest continuous use should not exceed 7 days. Long term use may lead to colonic melanosis and laxative dependent constipation.

2. Preoperative intestinal cleansing application effect

(1) Intestinal cleansing plan: Usually take 4-6 tablets (48-72mg sennoside) 12 hours before surgery, combined with 2000ml or more of water for drinking.

(2) Cleanliness assessment: Can achieve the required intestinal cleanliness for sigmoidoscopy, but inferior to polyethylene glycol electrolyte solution.

(3) Advantages and characteristics: Compared with hypertonic laxatives, senna glycosides have a lower risk of electrolyte imbalance and are more suitable for preoperative preparation in elderly patients.

3. Precautions for the use of Japanese PursennidTablets for clearing constipation

(1) Taboo difference: Patients with chronic constipation should not use intestinal obstruction; Preoperative bowel cleansing requires additional exclusion of cases at risk of gastrointestinal perforation.

(2) Dose adjustment: For chronic constipation, it is recommended to start with 1 tablet per day; Preoperative bowel cleansing requires sufficient use according to the standard protocol to ensure effectiveness.

(3) Monitoring requirements: Chronic constipation requires regular assessment of dependency; Preoperative application requires monitoring of dehydration and electrolyte balance.