During the treatment of Capivasertib, it is important to focus on managing common side effects such as nausea, rash, and stomatitis. Symptoms can be effectively controlled through graded management, symptomatic treatment, and preventive measures. The following are specific response plans.

1. Nausea management

(1) Drug intervention

For the first occurrence of nausea, prophylactic use of 5-HT3 receptor antagonists (such as ondansetron) is recommended. For nausea of grade 2 or above, administration should be suspended until it subsides to below grade 1.

(2) Dietary adjustments

It is recommended to eat small meals and avoid high-fat/spicy foods. Severe cases can be relieved by taking honey water or ginger juice orally, and daily weight monitoring to prevent dehydration.

2. Treatment of rash

(1) Classification measures

Continue medication and apply 1% hydrocortisone ointment locally for rash grades 1-2. Discontinue treatment for grade 3 until it subsides, and reduce dosage by 20% upon recovery.

(2) Skin care

Apply a mild cleansing product with pH 5.5 and a fragrance free moisturizer immediately after bathing. Avoid direct sunlight exposure and use SPF50+sunscreen when going out.

3. Coping with stomatitis

(1) Local treatment

Rinse 0.9% saline or lidocaine solution for pain relief, apply oral ulcer film on the ulcer surface, and take oral care three times a day.

(2) Nutritional support

Choose a warm and cool liquid diet and supplement with vitamin B family. Grade 3 stomatitis requires temporary suspension of medication and intravenous nutritional support, with a reduction of 15% after recovery.