Feneridone is a new non steroidal mineralocorticoid receptor antagonist, which is mainly used to treat chronic kidney disease and heart failure related to type 2 diabetes. The following provides a detailed explanation from three aspects: indications, dosage regimen, and side effects, all based on drug instructions and clinical research data.

1 Indications

Feneridone is suitable for adult patients with chronic kidney disease related to type 2 diabetes, which can reduce the risk of end-stage renal disease, cardiovascular death, etc. Clinical studies have shown that it can significantly reduce urinary protein excretion and delay renal function deterioration.

2-dose plan

(1) Standard dose

The initial dose is 10mg or 20mg once daily, and should be selected based on estimated glomerular filtration rate (eGFR) and blood potassium levels. The medication time is not affected by eating, but it needs to be fixed daily.

(2) Dose adjustment

When the blood potassium level exceeds 5.0mmol/L, the dosage should be reduced or temporarily suspended; When eGFR<25mL/min/1.73m ², the recommended starting dose is 10mg/day. Patients with severe liver dysfunction do not need to adjust the dosage.

3 Adverse Reactions

(1) Common side effects

Hyperkalemia (incidence about 18%), hypotension, dizziness, etc. Most of them are mild to moderate and can be controlled through monitoring and dose adjustment.

(2) Serious risk

Be alert to hyperkalemia related arrhythmias, and regularly monitor blood potassium and renal function during medication. Avoid combination therapy with potent CYP3A4 inhibitors.

4. Medication for special populations

Prohibited during pregnancy (may cause fetal damage); During lactation, one should weigh the pros and cons; Elderly patients do not need to adjust the dosage; The safety of children has not yet been established.

5 Precautions

EGFR and blood potassium levels need to be evaluated before medication, and a follow-up examination is required at the 4th week of treatment. Avoid a high potassium diet. If muscle weakness or arrhythmia occurs, seek medical attention immediately.