Valemetostat is an oral EZH1/EZH2 inhibitor used to treat hematological malignancies such as adult T-cell leukemia/lymphoma. Correctly mastering the methods of administration, principles of dosage adjustment, and handling of missed doses are crucial for ensuring efficacy and reducing toxicity.

1、 On an empty stomach or with meals?

1. Recommended way of taking

Valemetostat is usually recommended to be taken on an empty stomach. Generally refers to taking medication at least 1 hour before meals or at least 2 hours after meals to reduce the impact of food on drug absorption.

2. Avoid taking with specific foods

It should be avoided to consume grapefruit (grapefruit) and its juice together. Grapefruit may inhibit CYP3A enzyme, affect drug metabolism, increase blood drug concentration, and increase the risk of adverse reactions.

3. Drinking water delivery

Swallow the whole tablet in warm water, do not chew, crush, or pry open the tablet to avoid affecting the efficacy or increasing irritation.

4. Take medication at a fixed time

It is recommended to take medication at a relatively fixed time every day to help maintain a stable blood drug concentration and reduce missed doses.

2、 Principle of dose adjustment

1. Conventional dosage

The specific starting dose should strictly follow the doctor's prescription and drug instructions, and the recommended dose may vary for different indications and regions.

2. Adjust according to adverse reactions

If hematological toxicity (such as thrombocytopenia, neutropenia, anemia) or non hematological toxicity (such as fatigue, nausea, liver dysfunction) occurs, doctors may suspend medication, reduce dosage, or permanently stop medication based on the severity.

3. It is not recommended to make self adjustments

Patients are not allowed to increase or decrease the dosage or discontinue medication on their own. Any dose adjustment should be determined by the doctor based on blood routine, liver and kidney function, and clinical manifestations.

4. Regular monitoring

During the treatment period, regular check ups of blood routine, liver and kidney function, and electrolytes are necessary to promptly detect abnormalities and adjust the plan.

3、 Handling of missed services

1. When I think of it, the time until the next medication is relatively long

If a missed dose is found and it is still early before the next medication, it can be taken as soon as possible.

2. It is approaching the next medication time

If it is close to the next medication time, the missed dose should be skipped and the next medication should be taken according to the original plan.

3. Prohibition of double medication

Do not take double the dose at once to make up for missed doses, as it may cause serious adverse reactions.

4. Treatment after vomiting

If vomiting occurs after taking the medication, do not take it immediately and wait for the next scheduled time according to the original plan. If vomiting occurs frequently, inform the doctor promptly.

5. Record the situation of missed services

It is recommended to record the time of missed medication and the handling method, and inform the doctor during the follow-up visit to assess medication compliance and adjust guidance.