During the treatment with Valemetostat, nausea, decreased appetite, and fatigue are commonly reported discomforts in patients. Reasonable response can improve the quality of life and help adhere to treatment.

1、 Disgusting response

1. Adjust medication and meal times

Try to take medication on an empty stomach and avoid stimulating the stomach with both medication and food. After taking medication, do not immediately lie flat. You can sit up or move slowly appropriately.

2. Small and multiple meals

To avoid overeating at once, divide three meals into five to six small meals to reduce the burden on the stomach.

3. Choose light food

The food is mainly warm, cool, light and easy to digest, such as Congee, noodles, steamed eggs, soda biscuits. Avoid greasy, spicy, overly sweet, and strongly scented foods.

4. Maintain air circulation

The eating environment should be well ventilated to avoid nausea caused by oil smoke, perfume and other irritating smells.

5. Use antiemetic drugs if necessary

If nausea significantly affects eating, the doctor should be informed and an appropriate antiemetic medication should be prescribed after evaluation. Do not self medicate.

2、 Coping with Decreased Appetite

1. Eat small meals frequently and increase the frequency of eating

Don't force yourself to eat more at every meal, you can eat promptly when you feel hungry, even if you only take a few bites at a time.

2. Increase the nutritional density of food

Choose eggs, fish, tofu, dairy products, nuts and other foods rich in protein and calories, and a small amount can supplement nutrition.

3. Improve the taste of food

Lemon juice, vanilla, vinegar and other seasonings can be used appropriately to enhance appetite. Avoid overly bland or repetitive diets.

4. Moderate pre meal activity

Taking a walk or engaging in light activities before meals can help stimulate appetite.

5. Nutritional support when necessary

If weight loss persists or food intake is severely insufficient, it is recommended to consult a doctor or nutritionist and consider oral nutritional supplements.

3、 Coping with fatigue

1. Reasonably arrange rest

Ensure sufficient sleep and schedule short naps during the day to avoid overexertion.

2. Moderate activity

Taking light exercises such as walking and stretching based on physical strength can help alleviate fatigue and improve mood. Avoid vigorous exercise.

3. Save energy

Arrange important activities during periods of high energy, and ask family members to assist with daily affairs if necessary.

4. Ensure nutrition and hydration

Eat regularly and drink plenty of water to avoid exacerbating fatigue due to dehydration or hypoglycemia.

5. Investigate other reasons

If fatigue suddenly worsens, the doctor should be informed to investigate causes such as anemia, thyroid dysfunction, infection, or electrolyte imbalance.