Prussian Blue capsules are a special detoxifying agent mainly used to treat radioactive cesium and non radioactive thallium contamination. The drug was developed and produced by Heyl, a German company, and was approved for market by the US Food and Drug Administration (FDA) in October 2003.

1、 Drug name

Common name: Prussian Blue Capsules (Radiogardase)

Product Name: Radiogardase (Radioactive Protective Agent)

2、 Indications

Used for detoxification treatment through accelerated elimination rate in patients with known or suspected contamination of radioactive cesium (¹³ ⁷ Cs) and/or radioactive/non radioactive thallium in the body.

3、 Specifications and characteristics

Specification: Each capsule contains 0.5 grams of Prussian blue insoluble powder.

Appearance: Dark blue capsule with light blue "PB" lettering printed on it; The content is blue powder with uneven particle size.

4、 Main components

Active ingredient: insoluble ferrocyanide (II).

Chemical formula: Fe ₄ [Fe (CN) ₆] ∝.

Molecular weight: 859.3 daltons.

5、 Usage and dosage

Adults and adolescents: 3 grams (6 capsules) each time, 3 times a day, with a total daily dose of 9 grams.

Children (2-12 years old): 1 gram (2 capsules) each time, 3 times a day, with a total daily dose of 3 grams.

Timing of administration: Start treatment as soon as possible after suspected contamination.

6、 Dose adjustment and special treatment

People with swallowing difficulties: can open the capsule and mix it with light food or liquid to take.

Duration of treatment: Typically 30 days or longer, adjusted based on weekly urine and fecal radioactivity monitoring.

7、 Medication precautions

After meals: Taking with food can stimulate the excretion of cesium/thallium.

Omission handling: Not clearly stated, it is recommended to follow medical advice.

Vomiting treatment: Not explicitly stated, emergency measures such as gastric lavage should be combined in case of severe contamination.

Monitoring requirements:

Weekly testing of complete blood count, serum chemistry, and electrolytes.

Thallium contaminated patients need to monitor 24-hour urinary thallium (normal value<5 micrograms/liter).

8、 Medication for special populations

Pregnant women (Class C): There is no data on fetal harm, but the risk of untreated primary pollution is higher.

Breastfeeding period: Pregnant women are prohibited from breastfeeding due to contamination, as cesium/thallium can be transmitted through breast milk.

Children:

2-12 years old: Safety and efficacy have been confirmed.

0-2 years old: Safety has not been established.

Elderly people: Close monitoring of cardiac function and concomitant medication are necessary.

Patients with liver dysfunction: may have reduced efficacy (due to reduced bile excretion).

9、 Adverse reactions

Common reaction: Constipation (incidence rate of 24%, mainly mild to moderate).

Other risks:

The radiation absorption dose of gastrointestinal mucosa increases.

Electrolyte abnormalities (7% incidence of hypokalemia).

Blue staining of feces, oral mucosa, and teeth.

10、 Contraindications

There are no clear contraindications.

11、 Drug interactions

The combination with other antidotes does not affect the efficacy of Prussian blue.

12、 Storage method

Storage temperature: 20 ° C-25 ° C (short-term 15 ° C-30 ° C allowed).

Packaging: White anti child opening plastic bottle, 36 pills per bottle.

13、 Production information

Manufacturer: HauptPharma Berlin GmbH.

Distributor: HEYLChemisch-pharmazeutischeFabrik GmbH&Co.KG, Berlin.

Prussian blueinformation