Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) and the world's first commercially available selective cyclooxygenase-2 (COX-2) inhibitor. It exerts its therapeutic effects by inhibiting cyclooxygenase-2 to suppress prostaglandin production.

1、 Drug name

Celecoxib (trade name: CELEBREX) ®)

2、 Indications

Osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis in patients aged 2 years and above, ankylosing spondylitis, acute pain, primary dysmenorrhea.

3、 Specifications and characteristics

200mg: Capsules

4、 Main components

The active ingredient is celecoxib.

5、 Usage and dosage

Osteoarthritis: 200mg once daily or 100mg twice daily.

Rheumatoid arthritis: 100mg to 200mg twice daily.

Juvenile rheumatoid arthritis:

Weight 10-25kg: 50mg twice a day.

Weight>25kg: 100mg twice a day.

Ankylosing spondylitis:

Take 200mg once daily or twice daily.

Acute pain and primary dysmenorrhea:

On the first day, 400mg will be given for the first time, and 200mg will be added if necessary; 200mg will be given twice a day thereafter.

6、 Dose adjustment

Moderate liver dysfunction: dose reduction of 50%.

CYP2C9 weak metabolizers: The initial dose is halved.

Elderly patients: Starting from the lower limit of the dosage range.

7、 Medication precautions

Before and after meals: You can take it without considering the time of eating.

Missed service: No specific explanation, it is recommended to follow the principle of regular replacement service.

Vomiting: Unless otherwise specified, it is recommended to consult a physician.

8、 Medication for special populations

Pregnant women: Avoid using it after about 30 weeks of pregnancy.

Breastfeeding period: Use with caution.

Children: 2 years old and above can use it.

Elderly people: Close monitoring of adverse reactions is necessary.

9、 Adverse reactions

Common adverse reactions (>2%) include:

Gastrointestinal tract: abdominal pain, diarrhea, indigestion, bloating, nausea.

Whole body: peripheral edema, accidental injury.

Nervous system: dizziness, headache.

Respiratory system: pharyngitis, rhinitis, sinusitis, upper respiratory tract infections.

Skin: rash.

10、 Contraindications

Individuals who are allergic to celecoxib or medication ingredients.

Individuals allergic to sulfonamide drugs.

Patients undergoing coronary artery bypass surgery.

Aspirin allergy asthma patients.

11、 Drug interactions

Anticoagulants: increase the risk of bleeding.

Antihypertensive drugs: may weaken the antihypertensive effect..

Diuretics: May reduce diuretic effect

Digoxin: May increase blood drug concentration.

Lithium salt: may increase lithium levels.

Methotrexate: May increase toxicity.

Corticosteroids: increase the risk of gastrointestinal ulcers.

12、 Storage method

Store at room temperature of 20-25 ° C, allowing fluctuations within the range of 15-30 ° C.

13、 Important safety warning

May increase the risk of serious cardiovascular events.

May cause gastrointestinal bleeding, ulcers, or perforation.

Hepatotoxicity risk.

Risk of worsening hypertension.

Risk of heart failure and edema.

Renal toxicity risk.

celecoxibinformation