The mechanism of action of finasteride is mainly through the inhibition of 5 α - reductase, and the high levels of dihydrotestosterone (DHT) in the scalp and prostate are associated with hair loss and prostate hyperplasia.

1、 Drug name

Common name: Finasteride

Product Name: PROPECIA ®

2、 Indications

Suitable for the treatment of male only baldness (androgenic alopecia).

Not applicable to women. ‌

3、 Specifications and characteristics

Specification: Each tablet contains finasteride.

4、 Main components

Active ingredient: finasteride.

5、 Usage and dosage

Usage: Can be taken with or without food.

Effective time: It usually takes at least three months or more of daily use to observe therapeutic effects. It is recommended to continue using it to maintain efficacy and to regularly reassess. The effect will reverse within 12 months after stopping treatment.

6、 Dose adjustment

Elderly patients: Based on pharmacokinetic studies of 5 milligrams of finasteride, there is no need to adjust the dosage in elderly patients, but the efficacy of this product in elderly patients has not been established.

Liver dysfunction: Due to the fact that finasteride is mainly metabolized in the liver, patients with abnormal liver function should use it with caution.

Renal insufficiency: Patients with impaired renal function do not need to adjust the dosage.

7、 Medication precautions

Before and after meals: can be taken with or without food.

Omission: If there is a missed dose, there is no need to supplement it. The next dose should be taken according to the usual time, and double the dose should not be taken.

Vomiting/Overdose: In clinical studies, single doses up to 400 milligrams and daily doses of 80 milligrams taken continuously for three months did not cause adverse reactions. There is currently no specific treatment for overdose.

Other precautions:

This product can cause a decrease in serum prostate-specific antigen (PSA) levels. During use, any confirmed increase in PSA levels below the lowest point, even if still within the normal range for men who have not taken 5 α - reductase inhibitors, may indicate the presence of prostate cancer and should be evaluated.

8、 Medication for special populations

Pregnant women and women who may become pregnant: contraindications. Pregnant or potentially pregnant women should not take this product, nor should they come into contact with crushed or damaged pills, as absorption of finasteride may pose a risk to male fetuses. A normal and complete tablet coating can prevent contact with active ingredients.

Breastfeeding women: not applicable to females. It is not yet clear whether finasteride is excreted through human milk.

Child patients: Not applicable. The safety and efficacy of pediatric patients have not yet been established.

Patients with liver dysfunction: Use with caution.

Patients with renal insufficiency: No need to adjust dosage.

9、 Adverse reactions

The most common adverse reactions (incidence ≥ 1%, and higher than placebo group):

Decreased libido.

Erectile dysfunction.

Ejaculation disorders (including decreased semen volume).

Most patients will experience a resolution of adverse reactions after discontinuing medication or some patients continue treatment. The incidence of the above-mentioned adverse reactions decreased to ≤ 0.3% in the fifth year of treatment.

The reported adverse reactions after listing also include:

Allergic reactions.

Sexual dysfunction lasting until discontinuation of medication.

Male infertility and/or poor semen quality.

Testicular pain and bloody semen.

Male breast cancer, breast pain and swelling.

Depression, suicidal ideation, and behavior.

10、 Contraindications

Prohibited during pregnancy. ‌

Individuals allergic to any ingredient of this product are prohibited from using it. ‌

11、 Drug interactions

Cytochrome P450 related drug metabolism system: No clinically significant drug interactions have been identified yet. Finasteride does not seem to affect this enzyme system.

Other concomitant medications: In clinical studies, daily doses of 1 mg or higher of finasteride have been associated with various drugs such as acetaminophen, aspirin, alpha blockers, ACE inhibitors, benzodiazepines, beta blockers, calcium channel blockers, diuretics, H2 receptor antagonists, statins, etc NSAIDs、 There was no clinically significant interaction observed when quinolone antibiotics were used in combination.

12、 Storage method

Storage conditions: Store at room temperature of 15-30 ° C (59-86 ° F).

Attention: Keep the container sealed and moisture-proof. Women, especially pregnant or potentially pregnant individuals, should not come into contact with crushed or damaged PROPECIA pills.

Finasterideinformation