Precipitation calcium carbonate tablets are oral tablets of precipitation calcium carbonate recorded in the Japanese Pharmacopoeia, belonging to inorganic salt phosphate binders.

1、 Drug name

Product Name: Caltan Ingot 500

Common name: Precipitated Calcium Carbonate Tablets

2、 Indications

Improve hyperphosphatemia in patients with chronic renal insufficiency during storage and dialysis.

3、 Specifications and characteristics

Specification: Each tablet contains 500mg of precipitated calcium carbonate.

Appearance: White tablets.

Appearance dimensions: diameter 10.0mm, thickness 5.4mm, weight 600mg.

Identification code: "MMM505" printed on the side.

4、 Main components

Active ingredient: Precipitated Calcium Carbonate.

Additives: lactose hydrate, low degree of substitution hydroxypropyl cellulose, hydroxypropyl cellulose, magnesium stearate.

5、 Usage and dosage

Regular dosage: Adults usually take 3.0g of precipitated calcium carbonate daily, divided into three doses, orally taken immediately after meals.

Dose adjustment: It can be adjusted appropriately according to age and symptoms.

6、 Dose adjustment

If the effect is not significant after taking the medication continuously for 2 weeks, the medication should be stopped and consideration should be given to switching to other appropriate therapies such as limiting phosphorus intake.

7、 Medication precautions

Usage: Take immediately after meals (straight after).

Usage: If it is packaged in PTP, it should be taken out of the PTP plate to avoid ingestion and sharp edges piercing the esophageal mucosa.

Omission treatment: The literature does not specify it, it is recommended to take it regularly in divided doses every day.

8、 Medication for special populations

Elderly people: usually with decreased physiological function, medication should be administered with caution and reduced if necessary.

Child: Not mentioned.

Pregnancy/lactation period: not mentioned.

Comorbidity patients:

Individuals with heart/lung dysfunction: Elevated calcium levels may inhibit heart and lung function.

Constipation patients: may hinder calcium/phosphorus excretion.

Patients with hypercalcemia: may lead to worsening of symptoms.

Patients with gastric acid deficiency: may have poor efficacy due to reduced drug solubility.

9、 Adverse reactions

Metabolic abnormalities: electrolyte imbalance such as hypercalcemia and alkalosis.

Digestive tract: constipation (common), diarrhea, nausea, acid reflux secretion.

Liver: Elevated levels of gamma GTP, AST, LDH, ALP, and triglycerides.

Long term/high-dose administration: Kidney stones, urinary tract stones.

Allergic reaction: itching.

10、 Contraindications

Patients with hypothyroidism.

Individuals with a history of allergies to calcium carbonate.

11、 Drug interactions

Should be taken at intervals of at least 2 hours: Tetracycline antibiotics and Neoquinolone antibiotics.

Be cautious and use:

Sodium/calcium polystyrene sulfonate: may affect its absorption and excretion.

Quinidine: It may be affected by pH value.

Active vitamin D supplements: can easily lead to hypercalcemia.

Avoid consuming large amounts of cow's milk at the same time: it may cause milk alkali syndrome.

Rosuvastatin: It should be taken at least 1 hour before and after to avoid weakened efficacy.

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