Anamorelin works by stimulating the ghrelin receptor GHS-R1a.

1、 Drug name and main ingredients

1. Common name: Anamorelin Hydrochloride

2. Product Name: ADLUMIZ Tablets

3. Dosage form: Oral film coated tablets

4. Main ingredients: Each tablet contains 50mg of Anamolin Hydrochloride

2、 Indications

1. Cancer cachexia: cancer cachexia used to treat patients with non-small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer. The following conditions must be met:

Weight loss of ≥ 5% within 6 months accompanied by loss of appetite;

2. Simultaneously present at least two of the following: ① fatigue/weariness; ② Decreased overall muscle strength; ③ CRP>0.5mg/dL or hemoglobin<12g/dL or albumin<3.2g/dL.

3、 Specifications and characteristics

1. Specification: 50mg/tablet, light yellow film coated tablet, with a long diameter of about 14.1mm, a short diameter of about 6.6mm, a thickness of about 5.2mm, and a mass of about 364mg.

2. Packaging: 100 pieces/bottle (10 pieces x 10PTP board).

4、 Usage and dosage

1. Conventional dose: 100mg (2 tablets) once daily for adults, taken orally on an empty stomach (fasting within 1 hour after taking the medication).

2. Omission treatment: skip the dose for more than 6 hours and take it according to the original plan the next day; No need to take additional medication after vomiting.

3. Efficacy evaluation: If there is no weight gain or improvement in appetite within 3 weeks, the medication should be discontinued.

5、 Medication precautions

1. Monitoring requirements:

Regularly check electrocardiogram (PR/QRS/QT interval), liver function, blood glucose, and electrolytes before and during treatment.

If palpitations, jaundice, or persistent nausea occur, seek medical attention.

2. Dietary taboos:

Avoid grapefruit juice (which inhibits CYP3A4 metabolism).

6、 Medication for special populations

1. Pregnant women: prohibited (animal experiments show embryotoxicity).

2. Breastfeeding period: Breastfeeding is prohibited during the treatment period and within one week after discontinuation of medication.

3. Liver injury:

Moderate (Child Pugh B) should be reduced to 50mg/day;

Severely (Child Pugh C) prohibited.

4. Elderly individuals: No need to adjust dosage, but close monitoring of cardiac function is necessary.

7、 Adverse reactions

1. Common (≥ 5%): Abnormal electrocardiogram (10.7%), high blood sugar (4.3%), liver dysfunction (6.4%), nausea (35%), diarrhea (13%).

2. Serious reactions: atrioventricular block, QT interval prolongation, acute liver injury.

8、 Contraindications

1. Individuals who are allergic to ingredients;

2. Patients with congestive heart failure, myocardial infarction, or angina pectoris;

3. Severe conduction system disorders (such as complete atrioventricular block);

4. Combination therapy with potent CYP3A4 inhibitors such as clarithromycin and itraconazole.

9、 Drug interactions

1. CYP3A4 inhibitors: Strong inhibitors (such as ketoconazole) increase blood drug concentration by 3.2 times;

2. CYP3A4 inducer: Rifampicin reduces blood drug concentration by 68%;

3. Antiarrhythmic drugs: Combination use may increase the risk of QT interval prolongation.

10、 Storage method

Store at room temperature (20-25 ° C), away from light and moisture. PTP packaging should be taken out before consumption.

Anamorelininformation