Anamorelin works by stimulating the ghrelin receptor GHS-R1a.

1、 High blood sugar and insulin resistance

Core risk: Anabolin can directly increase blood glucose and induce peripheral insulin resistance. Even people without a history of diabetes may have abnormal blood glucose.

Monitoring requirements: Fasting blood glucose and glycated hemoglobin must be tested before medication. It is recommended to monitor blood glucose levels 2-3 times a week during the initial stage of treatment.

High risk population: Elderly, obese, or individuals with impaired glucose tolerance have a significantly increased risk of developing high blood sugar and require strengthened monitoring.

Response strategy: If blood sugar continues to be high, it is necessary to use or adjust hypoglycemic drugs (such as metformin, insulin) under the guidance of a doctor. It is not recommended to take hypoglycemic drugs on your own.

2、 QT interval prolongation

Potential impact: This product may cause mild prolongation of QTc interval on electrocardiogram, increasing the risk of malignant arrhythmia.

High risk patients: those with a history of long QT syndrome, bradycardia, electrolyte imbalance (low potassium, low magnesium), or currently using other drugs that can cause QT prolongation have a higher risk.

Baseline screening: Electrocardiogram should be rechecked before and during medication to monitor changes in QTc values. If the absolute value is greater than 500ms or the increase from baseline is greater than 60ms, drug discontinuation should be considered.

Avoid co use: Try to avoid co use with diuretics (causing low potassium), class I/III antiarrhythmic drugs, or macrolide antibiotics.

3、 Other core precautions

Monitoring weight and edema: during the medication period, the weight and edema of lower limbs should be monitored at the same time to be alert to the aggravation of heart failure due to fluid retention.

Liver function tracking: This product is metabolized by the liver, and transaminases need to be regularly checked during medication to prevent accumulation of liver function damage.

Take medication on time: It is recommended to take medication on an empty stomach or with meals at a fixed time every day to develop a regular habit.

Do not stop abruptly: If medication needs to be stopped, it should be gradually reduced under the guidance of a physician to avoid metabolic fluctuations.

Safety Notice: If you experience palpitations, dizziness, or severe thirst with polyuria, seek medical attention immediately.