Dotinurad, as a uric acid excretion enhancer, has contraindications mainly related to severe renal insufficiency, allergic reactions, and specific drug combinations, which should be strictly followed to avoid serious adverse reactions.

Taboos related to renal function

(1) Severe renal impairment: Patients with estimated glomerular filtration rate (eGFR)<30mL/min are contraindicated.

(2) End stage renal disease: Patients who require hemodialysis or peritoneal dialysis are prohibited from using it.

2 Allergy and special physical contraindications

(1) Allergy to drug ingredients: Do not use for those who are allergic to Duodenafil or any excipients in the preparation.

(2) Hereditary xanthinuria: may exacerbate uric acid excretion disorders and lead to complications.

3 contraindications for drug interactions

(1) Combination use of pyrazinamide: can antagonize the uric acid lowering effect and increase the risk of adverse reactions.

(2) Combination use of ethambutol: may cause abnormal fluctuations in uric acid levels.

4 Other taboo situations

(1) Pregnancy period: Lack of safety data, pregnant women should avoid using it.

(2) Breastfeeding period: Medications may be secreted through breast milk, and breastfeeding women should avoid using them.