During the use of Dotinurad, it is important to pay close attention to the risks related to the kidneys, liver, and joints, and to take preventive measures and monitoring to ensure safe medication. The following are the core precautions.

1、 Risk and prevention of kidney stones

Adequate hydration: Maintain a daily water intake of at least 2 liters and evenly distribute throughout the day to avoid excessive concentration of urine.

Avoid using concomitant medications that can cause stones: Try to avoid using high-dose vitamin C, calcium supplements, or thiazide diuretics in combination. If necessary, strengthen monitoring.

Stop immediately if symptoms appear: If you experience lower back pain, hematuria, or painful urination, you should suspend medication and seek medical attention as soon as possible for investigation.

2、 Key points of liver function monitoring

Baseline testing before medication: Prior to initiating treatment, ALT, AST, and total bilirubin must be tested to ensure no active liver disease.

Regular review frequency:

Initial 3 months: Liver function testing once a month.

After stabilization, it can be extended to a re examination every 3-6 months.

Principle of abnormal handling: Continue medication and strengthen monitoring when transaminase levels rise to within 3 times the upper limit of normal; Consider reducing the amount when 3-5 times and investigate the reason; If it exceeds 5 times or is accompanied by elevated bilirubin, the medication should be stopped immediately and medical attention should be sought.

3、 Prevention of acute gout attacks

Preventive combination therapy: It is recommended to use low-dose colchicine or nonsteroidal anti-inflammatory drugs in combination during the first 4 to 6 months of starting treatment with Duodenafil to reduce the risk of acute attacks.

Do not stop taking medication during an attack: If an acute gout attack occurs, continue taking Duodenafil and follow the usual protocol to control inflammation and avoid worsening blood uric acid fluctuations.

Long term monitoring and communication: If recurrent, follow-up visits are needed to evaluate whether the rate of uric acid lowering is appropriate, and adjust the combination therapy plan if necessary.

4、 Other important reminders

If renal and liver dysfunction occur at the same time, priority should be given to treating kidney injury and consulting a specialist physician.

All medication adjustments should be made under the guidance of a doctor, and do not change the dosage or discontinue use on your own.