Adagrasib is a targeted anti-cancer drug primarily used to treat non-small cell lung cancer with KRASG12C mutation. Its common side effects include gastrointestinal reactions, fatigue, liver dysfunction, etc. Most of them can be relieved through symptomatic treatment, but serious side effects require timely medical attention.

1. Common side effects and mitigation methods

(1) Gastrointestinal reactions: such as nausea, vomiting, diarrhea, etc. It is recommended to have small and frequent meals, avoid greasy foods, and use antiemetic or antidiarrheal medication if necessary

(2) Fatigue: Maintain sufficient rest, engage in appropriate activities, and avoid overexertion

(3) Abnormal liver function: Regularly monitor liver function indicators, avoid drinking alcohol and using hepatotoxic drugs

2. Serious side effects that require medical attention

(1) Interstitial lung disease: If new or worsening symptoms such as cough, difficulty breathing, fever, etc. appear, seek medical attention immediately

(2) QT interval prolongation: manifested as palpitations, dizziness, syncope, etc., requiring regular electrocardiogram monitoring

(3) Severe liver function damage: such as jaundice, clay colored stool, dark urine, etc., immediate discontinuation of medication and medical attention are required

3. Precautions for special populations

(1) Patients with liver dysfunction: dosage should be adjusted according to the degree of liver function damage

(2) Pregnant women: with fetal toxicity, strict contraception is required during medication

(3) Elderly patients: may be more sensitive to side effects and require close monitoring

4. Drug interactions

(1) Avoid combination with potent CYP3A inhibitors or inducers as it may affect drug concentration

(2) Caution should be exercised when using drugs that prolong the QT interval, as it may increase the risk of cardiac toxicity

(3) Combination with gastric acid inhibitors may reduce the absorption of adagracilib