Dienogest, as a highly effective progestogen preparation, should be strictly followed in terms of contraindications, dietary restrictions, and usage limitations. The following provides a detailed explanation from three aspects: taboo groups, taboo foods, and special restrictions.

1. Taboo population

(1) Pregnant women: May interfere with fetal development, pregnancy should be ruled out before medication.

(2) Breastfeeding women: Medications can be secreted into breast milk, and should not be used during lactation.

(3) Severe liver function impairment: Not recommended for Child Pugh C patients.

(4) History of thrombosis: Patients with deep vein thrombosis, pulmonary embolism, etc. are prohibited from using it.

(5) Hormone dependent tumors: such as breast cancer and endometrial cancer patients are forbidden.

2. Forbidden foods

(1) Grapefruit and its products: may inhibit CYP3A4 enzyme and increase blood drug concentration.

(2) St. John's wort: induces CYP3A4 enzyme and reduces drug efficacy.

(3) Alcohol: may increase the burden on liver function, it is recommended to limit intake.

3. Restrictive conditions

(1) Cardiovascular risk: Patients with hypertension need to regularly monitor their blood pressure.

(2) Metabolic impact: diabetes patients need to strengthen blood glucose monitoring.

(3) Fertility: It is recommended to wait for 3 months after discontinuing medication before preparing for pregnancy.

(4) Special examination: During medication, thyroid function test results may be affected.

(5) Preoperative discontinuation: Medication should be discontinued 4 weeks before elective surgery to reduce the risk of thrombosis.