Amino acid compound granules (Es Polytamin), as a nutritional supplement, mainly have the effect of correcting amino acid metabolism imbalance. Drug interactions should pay attention to potential effects with other metabolic pathway drugs. The following will explain from three aspects: pharmacological effects, clinical effects, and interactions.

1. Effect of action

(1) Nutritional support: Provides essential and non essential amino acids to improve protein synthesis disorders, suitable for hypoalbuminemia or postoperative nutritional supplementation.

(2) Metabolic regulation: By optimizing the amino acid ratio and correcting the abnormal ratio of branched chain amino acids/aromatic amino acids, it assists in the management of hepatic encephalopathy.

(3) Organizational repair: promotes wound healing, especially suitable for pathological conditions such as burns and injuries where protein loss is significant.

2. Drug interactions

(1) Medications affecting liver microsomal enzymes: Combination with potent CYP3A4 inhibitors may alter the rate of amino acid metabolism and require monitoring of blood drug concentrations.

(2) Electrolyte regulating drugs: Combined use with potassium sparing diuretics may exacerbate the risk of hyperkalemia, referring to the interaction mechanism of eplerenone.

(3) Anticoagulants: may enhance the efficacy of warfarin, similar to the effect of Lucaparib on CYP2C9 substrates.

(4) Neuropharmaceuticals: When used in combination with P-gp substrates, caution should be exercised, referring to the inhibitory effect of sulfatinib succinate on transporters.

(5) Proton pump inhibitors: may reduce amino acid absorption rate. It is recommended to take them every 2 hours, following the relevant warnings of Rucaparib.