As an intestinal anti-inflammatory drug, special attention should be paid to dosage management, adverse reaction monitoring, and medication for special populations when using mesalazine. The following provides detailed explanations on routine precautions, handling of missed doses, and response to adverse reactions.

1. Precautions for routine medication

(1) Dose management

Strictly follow the doctor's instructions for dosage, enteric coated tablets should be swallowed whole and not chewed. Regular monitoring of liver and kidney function, as well as blood routine, is required during the treatment period.

(2) Medication time

It is recommended to have a fixed daily medication time and take it with food to reduce gastrointestinal irritation, but enteric coated preparations need to be taken on an empty stomach to ensure efficacy.

2. Leakage Handling Plan

(1) Short term missed service

If the missed dose is less than 6 hours, it should be taken immediately. If it exceeds 6 hours, the dose will be skipped and the next dose will be taken according to the original plan.

(2) Vomiting treatment

Vomiting after taking medication should not be accompanied by additional doses, and the original dosing plan should be maintained. Frequent vomiting requires medical attention to adjust medication administration.

3. Adverse reaction management

(1) Gastrointestinal reactions

Common symptoms such as nausea and diarrhea are usually mild and tolerable. Severe diarrhea requires timely fluid replacement and medical attention.

(2) Allergic reactions

If allergic reactions such as rash and difficulty breathing occur, medication should be stopped immediately and medical attention should be sought. If necessary, anti allergic treatment should be administered.

4. Medication for special populations

(1) Pregnancy and lactation period

Pregnant women need to evaluate the benefit risk ratio, and breastfeeding should be suspended during the medication period for lactating women.

(2) Liver and kidney dysfunction

Patients with mild to moderate liver and kidney function impairment do not need to adjust the dosage, while those with severe impairment should use it under the guidance of a doctor.

5. Drug interactions

Combined use with anticoagulants may increase the risk of bleeding, and close monitoring of adverse reactions is necessary when combined with immunosuppressants.