As a local androgen receptor inhibitor for the treatment of acne, Winlevi cream commonly has side effects such as skin irritation and dryness. Most symptoms can be relieved by adjusting the usage method, and serious adverse reactions require timely medical treatment.

1. Common side effects and alleviation

(1) Dry skin: About 25% of users experience it. It is recommended to apply oil-free moisturizer 30 minutes after taking the medication.

(2) Local stimulation: 15% -20% reported burning sensation, initially can be used every other day to establish tolerance.

(3) Scattered erythema: The incidence rate is about 12%. Avoid using it in combination with other keratolytic agents (such as salicylic acid).

2 Precautions for Special Groups

(1) Pregnancy: Animal studies have shown fetal toxicity, and women of childbearing age need to use contraception for one month after discontinuing the medication.

(2) Breastfeeding period: The systemic absorption rate of local medication is less than 1%, but it is recommended to avoid using it in the breast area.

(3) Children: Safety has not been established for children under 12 years old, and growth and development should be monitored for adolescent patients.

3. Prevention of Drug Interactions

(1) Avoid combination use: Other topical retinoids may exacerbate skin irritation.

(2) Caution in combination: Skincare products containing alcohol may enhance dryness side effects.

(3) Monitoring requirements: Regular liver function checks are required when combined with systemic anti androgen drugs.

4. Treatment of serious adverse reactions

(1) Contact dermatitis: Stop immediately and apply cold compress. If necessary, use topical corticosteroids.

(2) Skin atrophy: permanent discontinuation of medication is required after long-term use.

(3) Allergic reaction: Emergency treatment is required when manifested as edema or difficulty breathing.