Acoramidis is a medication used to treat specific cardiovascular diseases, and its indications and medication precautions must strictly follow medical advice. The following is a detailed explanation:

Akomidi indications

1. Main therapeutic areas

Suitable for the treatment of adult transthyretin amyloidosis cardiomyopathy (ATTR-CM), which can delay disease progression.

2. Mechanism of action

By stabilizing the tetramer structure of transthyretin, the formation and deposition of amyloid fibers are reduced.

Medication precautions

1. Dosage and Administration

The standard dosage is once daily oral administration, and the whole pill should not be chewed. If the missed dose exceeds 12 hours, the dose should be skipped.

2. Monitoring requirements

Liver function should be evaluated before treatment, and regular monitoring of electrocardiogram and liver function indicators should be conducted during treatment.

3. Special populations

Prohibited during pregnancy, breastfeeding should be suspended during lactation. Elderly patients do not need to adjust their dosage.

4. Drug interactions

Avoid combining with potent CYP3A4 inducers as it may reduce efficacy.

5. Adverse reaction management

Common symptoms of diarrhea can be alleviated by adjusting diet, and severe cases require medical attention.

Special Warning

1. Abnormal liver function

When jaundice or elevated transaminase levels exceed 3 times ULN, treatment should be interrupted.

2. Abnormal cardiac conduction

May cause atrioventricular block and require regular electrocardiogram monitoring.

Storage conditions

1. Temperature control

It is recommended to store within the range of 20 ° C to 25 ° C (68 ° F to 77 ° F) and allow short-term exposure to an environment of 15 ° C to 30 ° C (59 ° F to 86 ° F).

2. Light avoidance requirements

Keep in the original packaging and avoid direct sunlight. The aluminum foil bag on the outer packaging of drugs has a light shielding function, and it still needs to be kept in a light shielding state after opening.

3. Humidity management

The relative humidity of the storage environment should be below 60% to prevent the drugs from getting damp and deteriorating. Suggest using desiccants for storage.

Special precautions

1. Travel carrying

Short distance travel can be carried at room temperature, but if it exceeds 24 hours, an insulated bag must be used to maintain a suitable temperature.

2. Exception handling

If the physical properties of the drug change, such as discoloration, clumping, or odor, it should be immediately stopped from use.

3. Child safety

It must be stored in a safe location out of reach of children, and it is recommended to use a lockable medicine box for safekeeping.