As an external nonsteroidal anti-inflammatory drug, the use of Eflofen patch should focus on three aspects: skin irritation reactions, drug interactions, and contraindications for special populations. The precautions for its use involve handling local adverse reactions, avoiding risks of combination therapy, and identifying contraindications. The following sub items detail the key management points.

1. Skin irritation management

(1) Local reactions: There may be redness, itching, or burning sensation at the application site. It is recommended to test a small area of the skin before the first use. If there is continuous irritation, it should be discontinued.

(2) Usage guidelines: Avoid using on damaged or inflamed skin, replace no more than 1 patch per day, and use the same area continuously for no more than 2 weeks to prevent accumulation of irritation.

(3) Allergy treatment: When contact dermatitis occurs, the patch should be removed immediately and the affected area should be cleaned. In severe cases, antihistamines should be used for treatment.

2. Drug interactions

(1) Oral NSAIDs: Combination with systemic nonsteroidal anti-inflammatory drugs may increase the risk of gastrointestinal bleeding, and gastrointestinal symptoms need to be monitored.

(2) Anticoagulants: may enhance the effectiveness of anticoagulants such as warfarin, and INR values need to be monitored more frequently during combination therapy.

(3) Diuretics: Combined use with thiazide diuretics may weaken the antihypertensive effect, and hypertensive patients need to adjust the dosage.

3. Taboo population

(1) Allergy history: People who are allergic to NSAIDs or patch excipients are prohibited from using aspirin. Aspirin asthma patients are a high-risk group.

(2) Skin lesions: Do not apply to individuals with active eczema, infectious skin diseases, or extensive skin lesions.

(3) Special population: contraindicated in late pregnancy, weighing the pros and cons during lactation; Insufficient data on child safety, not recommended for use.

4. Other precautions

(1) Absorption control: Avoid using heating pads or electric blankets simultaneously, as localized heating may increase the system's absorption capacity.

(2) Site selection: Priority should be given to applying to the proximal limbs, avoiding joint activity areas to prevent detachment. Applying to the chest may affect breathing.

(3) Disposal: After use, the patch should be folded and bonded before being discarded to prevent children or pets from accidentally touching residual medication.