Proper use of Vemlidy is the foundation for ensuring efficacy and safety, with core requirements including taking with meals, strict dosage management, and standardized handling of missed doses.

1、 Requirements for taking with meals

Each dose must be taken with meals: each dose must be taken with food, significantly reducing fasting absorption and affecting blood drug concentration.

Meals should contain an appropriate amount of fat: it is recommended to pair with high-fat meals (about 400kcal, with fat accounting for about 25% to 30%), such as meat, eggs, dairy products, or dishes cooked with cooking oil; A very low-fat diet (such as eating only fruits and clear soup) can significantly reduce drug absorption.

Fixed meal schedule: Taking the same main meal (such as lunch or dinner) with meals daily can help maintain a stable blood drug concentration and medication habits.

2、 Principle of dose adjustment

Strictly follow the doctor's advice for medication: The regular dosage is once a day, one tablet per time (25mg), and should not be adjusted or stopped on your own.

Renal function adjustment: For patients whose creatinine clearance rate is lower than 15mL/min or who are undergoing dialysis, the interval of administration should be adjusted or stopped after evaluation by the doctor; Mild to moderate renal insufficiency usually does not require adjustment.

Liver function impact: Patients with decompensated liver disease should consult a specialist before use and may need to strengthen monitoring.

Attention to combined medication: Co administration with certain antiepileptic drugs, anti tuberculosis drugs, or St. John's wort may reduce efficacy, and the plan needs to be adjusted by the doctor.

3、 Handling methods for missed services

Short term missed medication (≥ 12 hours from next medication): Take it as soon as possible and resume regular time thereafter.

Approaching the next medication time (less than 12 hours away from the next medication): skip missed doses, take the next dose on time, and prohibit double dose supplementation.

Post vomiting treatment: Vomit within 1 hour after taking the medication. If the stomach contents show the entire tablet, an additional dose can be taken; If vomiting occurs within 1 hour or cannot be determined, there is no need to take the next dose as usual.