During the period of taking propafenone fumarate tablets, it is important to pay close attention to three serious adverse reactions: nephrotoxicity, decreased bone density, and lactic acidosis. Early identification and standardized monitoring can effectively reduce risks.

1、 Renal toxicity

Regular monitoring of renal function: Serum creatinine, blood phosphorus, and urine routine (such as urine protein and urine sugar) should be regularly tested before medication and during treatment to evaluate renal tubular function.

Avoid co administration of nephrotoxic drugs: Avoid co administration with nonsteroidal anti-inflammatory drugs, aminoglycoside antibiotics, or contrast agents; If necessary, strengthen monitoring under the guidance of a doctor.

Maintaining sufficient water intake: Drinking water in portions daily and maintaining adequate urine output can help reduce the concentration load of drugs in the renal tubules.

Timely adjustment in case of abnormalities: If there is a significant increase in blood creatinine or a significant decrease in blood phosphorus, a doctor should evaluate whether to reduce or stop the medication.

2、 Decreased bone density

Baseline bone density assessment: For long-term medication users, especially those with a history of osteoporosis or postmenopausal women, it is recommended to undergo regular bone density testing before and during treatment.

Supplementing calcium and vitamin D: Increase dairy products, soy products, and dark green vegetables in daily diet; If necessary, supplement calcium supplements and vitamin D preparations under the guidance of a doctor.

Persist in weight-bearing exercise: Regular walking, jogging, and other weight-bearing exercises can help maintain bone health.

Avoid additional risk factors: limit excessive alcohol and smoking, and reduce adverse effects on bone metabolism.

3、 Lactic acidosis

Identify early symptoms: If there is unexplained extreme fatigue, muscle soreness, shortness of breath, abdominal pain, nausea, or drowsiness, be alert to lactic acidosis.

High risk groups should be more vigilant: those with severe liver disease, heavy drinking history, diabetes or other nucleoside analogues are at higher risk and should be closely observed.

Immediate discontinuation of medication for medical treatment: If suspected of lactic acidosis, this product should be immediately discontinued and emergency medical attention should be sought to test arterial blood lactate levels and receive supportive treatment from a doctor.