Propenofovir fumarate tablet (Vemlidy) is a highly effective anti hepatitis B virus drug, which is mainly used for the antiviral treatment of chronic hepatitis B. It has the characteristics of strong targeting and low drug resistance, and is suitable for adult and adolescent patients.

1 Core Indications

(1) Treatment for chronic hepatitis B virus infection, suitable for patients aged 12 years and above with a weight of ≥ 35kg.

(2) Long term viral suppression therapy for patients with compensatory liver disease.

2 Characteristics of applicable population

(1) Chronic hepatitis B infected persons with positive HBV DNA test.

(2) Newly diagnosed patients or those who have poor response to other nucleoside analogue treatments.

3 treatment mechanisms

(1) As a prodrug of tenofovir, it selectively inhibits HBV DNA polymerase.

(2) Terminate the virus replication process by incorporating viral DNA strands.

4 Special precautions

(1) Patients with renal insufficiency need to adjust their dosage according to creatinine clearance rate.

(2) HIV co infected individuals need to combine a complete antiretroviral regimen.