During the treatment with adatinib, diarrhea, fatigue, and dry skin are common adverse reactions that affect quality of life. Proactively managing these symptoms can help maintain treatment intensity and daily status. The following sub items provide coping suggestions.

1、 Diarrhea management

When there is loose stool or an increase in bowel movements, first increase drinking water or oral rehydration salts to prevent dehydration.

Choose foods with low fiber and easy digestion (such as porridge, bananas, toast), and avoid greasy, spicy or dairy products.

If diarrhea persists or worsens, it is necessary to inform the doctor in a timely manner and evaluate whether to use antidiarrheal drugs or adjust the treatment dosage.

2、 Fatigue management

Reasonably arrange rest and light activities (such as short walks) to avoid prolonged bed rest and further decline in energy.

Simplify daily tasks by priority and seek help from family members to share household chores or work when necessary.

Pay attention to nutrient intake and eat small meals frequently; If fatigue suddenly worsens or affects basic self-care, seek medical attention promptly to investigate potential causes such as anemia or thyroid dysfunction.

3、 Skin dryness care

Apply fragrance free moisturizer multiple times a day, especially when the skin is slightly damp after bathing, to lock in moisture.

The temperature of the bath water should not be too high, and the time should be controlled within 10 minutes. Avoid using soap products with strong alkalinity.

If there is severe flaking, cracking, or itching, the doctor should be informed that special repair products containing urea or ceramide may be needed.