Pazopanib is an oral targeted drug, and standardized administration, reasonable management of missed doses, and dosage adjustments are the core to ensure efficacy and safety. The following provides concise guidelines from three aspects: administration methods, handling of missed doses, and dosage adjustments.

1、 Usage method

1. Medication time and fasting requirements

It should be taken on an empty stomach, 1 hour before or 2 hours after meals.

Swallow the whole piece, do not crush or chew.

2. Regular frequency of use

Once a day, it is recommended to take it at the same time every day to maintain stable blood drug concentration.

3. Avoid food affecting absorption

A high-fat diet can significantly increase drug absorption, potentially raising blood drug concentrations and toxicity risks, so it is essential to strictly adhere to fasting requirements.

2、 Handling of missed services

1. Rules for replenishing missed services

If it is less than 12 hours before the regular medication time, it can be taken immediately, and the next time it will still be taken at the original time.

If it has exceeded 12 hours, skip this missed dose and take it on time for the next time. Do not double the dosage.

2. Handling of special circumstances

If vomiting occurs after taking the medication, it is not recommended to increase the dosage and wait for the next dose according to the usual time.

3、 Dose adjustment

1. Standard starting and adjustment criteria

The recommended starting dose is 800mg/day.

Dose adjustment should be based on tolerance factors such as liver function, blood pressure, and skin reactions on hands and feet. The doctor should decide to gradually reduce the dosage (such as 400mg/day) and should not increase or decrease it on their own.

2. Interactions with other drugs

When used in combination with potent CYP3A4 inhibitors (such as clarithromycin) or inducers (such as rifampicin), the dosage should be reassessed by a doctor to avoid self combination.

3. Dosage principles for patients with liver function impairment

For patients with mild to moderate liver function impairment, it is recommended to reduce dosage or use with caution. For those with severe impairment, it is generally not recommended to use. The specific plan must strictly follow the doctor's advice.