Rufinamide is a new type of triazole derivative antiepileptic drug developed by Eisai Corporation in Japan. It effectively reduces abnormal neuronal discharges by regulating the activity of voltage-gated sodium ion channels in the brain, providing a new strategy for epilepsy treatment.

1、 Drug name

Common name: Rufinamide

Product Name: Banzel

2、 Indications and Target Population

Suitable for adjuvant treatment of Lennox Gastaut syndrome related epileptic seizures in children aged 1 year and above and adults.

3、 Specifications and characteristics

Specification: 100mg, 100 pieces per box.

Appearance: Thin film coated sheet.

4、 Main components

Active ingredient: Lufenamide.

5、 Usage and dosage

Adult patients: starting dose of 400-800mg/day, divided into 2 doses, increasing by 400-800mg every 2 days, with a maximum daily dose of 3200mg.

Child patients (≥ 1 year old): The initial dose is 10mg/kg/day, divided into 2 doses, with an increase of 10mg/kg every 2 days. The maximum daily dose is 45mg/kg (not exceeding 3200mg).

Administration method: It should be taken with food, and the film coated tablets can be taken in whole, half, or crushed form.

6、 Dose adjustment

Combination use of valproic acid: The initial dose for pediatric patients should be less than 10mg/kg/day, and for adults it should be less than 400mg/day.

Liver function impairment: It is contraindicated for patients with severe liver function impairment, and should be used with caution for patients with mild to moderate liver function impairment.

Hemodialysis: Dialysis will reduce the drug exposure by about 30%, and the dosage needs to be adjusted during dialysis.

7、 Medication precautions

Medication time: It must be taken together with food to improve bioavailability.

Omission treatment: If you forget to take your medication, you should take the regular dose at the next normal medication time and do not double the dosage.

Vomiting treatment: If vomiting occurs shortly after taking medication, it is necessary to consult a doctor to determine whether supplementation is needed.

8、 Medication for special populations

Children: Patients over 1 year old should strictly calculate the dosage according to their weight.

Pregnant/breastfeeding period: There is currently no clear research data available, and the pros and cons need to be weighed.

Elderly patients: The dosage should be adjusted according to renal function.

9、 Adverse reactions

Common reactions (≥ 10%): headache, dizziness, fatigue, drowsiness, nausea.

Neurological reactions: tremors, unstable walking, abnormal eye movements.

Digestive system reactions: decreased appetite, vomiting, diarrhea.

Serious adverse reactions: suicidal tendencies, severe rash, arrhythmia, immediate medical attention is required.

10、 Contraindications

Prohibited for individuals allergic to Lufenamide or excipients; Patients with severe liver function impairment are prohibited from using it.

11、 Drug interactions

The initial dose needs to be adjusted when combined with valproic acid; Co administration with central nervous system inhibitors may exacerbate drowsiness reactions.

12、 Storage method

Store in a sealed container at room temperature, avoid moisture, and keep out of reach of children.

13、 Manufacturer

Developed and produced by Eisai, a Japanese company.

Rufinamidinformation