Olmesartan medoxomil was developed by Daiichi Sankyo Co., Ltd. in Japan and is an important member of the angiotensin II receptor antagonist (ARB) class of drugs.

1、 Drug name

Olmesartan Medoxomil, also known as Olmetec.

2、 Indications

Hypertension.

3、 Specifications and characteristics

Specifications: The tablet specifications include orally disintegrating tablets (OD tablets) 40mg.

Description: The specifications and appearance are as follows: OD ingot 40mg is a white to slightly yellow white circular tablet with a diameter of 9.6mm, a thickness of about 4.7mm, and a weight of about 320mg.

4、 Main components

The active ingredient is Olmesartan Medoxomil.

5、 Usage and dosage

Typical dosage: Adjust appropriately according to age and symptoms. The maximum daily dose should not exceed 40mg.

Usage: Tablets can be placed on the tongue and soaked in saliva to disintegrate or swallowed with water. Do not take medication while lying flat without using water.

6、 Dose adjustment

Individuals with renal impairment: Low doses should be used initially and with caution, and the dosage should be adjusted slowly.

Patients with liver function impairment: No special adjustment is needed, but data shows that it may have an impact on increasing blood drug concentration. When taking medication, attention should be paid, and low doses can be used and observed.

Elderly patients: It is necessary to take the medication according to the initial dosage and use it with caution.

7、 Medication precautions

Preparation before taking: After opening the bottle, it must be stored against moisture.

Swallowing method: It can be soaked in saliva on the tongue or taken with water.

Handling of missed doses: If not specifically stated in the drug instructions, it is generally recommended to take the missed dose as soon as possible. If the next dose is approaching, the missed dose should be skipped and double the dose should not be taken at the same time.

Vomiting: The instruction manual does not provide specific recommendations. If you experience vomiting or suspect that the medication has not been absorbed after taking it, you can contact a doctor.

Important medication reminder: During the medication period, symptoms such as dizziness and fatigue related to lowering blood pressure may occur. Be extra vigilant when working at heights, driving, or operating dangerous equipment. It is best to stop taking medication 24 hours before surgery to prevent severe hypotension.

8、 Medication for special populations

Pregnant and potentially pregnant women: Do not use. The serious risks reported for the use of ARBs or ACEIs during and after pregnancy include oligohydramnios, death, neonatal hypotension, renal failure, and underdeveloped lungs and skull.

Breastfeeding women: It is recommended not to breastfeed. In animal experiments, milk migration was observed at 5mg/kg/day.

Children and adolescents: No clinical studies have been conducted.

Elderly: It is recommended to start medication at the starting dose and be cautious of excessive blood pressure reduction.

9、 Adverse reactions

Common side effects include dizziness, headache, fatigue, etc. More serious side effects include:

Major: vascular edema, liver dysfunction, kidney failure, hyperkalemia, hypoglycemia, rhabdomyolysis, anemia, thrombocytopenia, severe diarrhea, interstitial pneumonia, allergies or anaphylactic shock, etc. (frequency unknown).

Other side effects: Symptoms with a frequency of less than 1-5% include rash, dry mouth, nausea, low blood pressure, increased heart rate, and abnormal clinical test values (such as elevated transaminase levels).

Rare side effects: May cause taste abnormalities, hair loss, sleep disorders or discomfort, loss of consciousness, etc.

10、 Contraindications

The following patients are not allowed to take medication:

Allergic to olmesartan medoxomil or its excipients.

Pregnant or potentially pregnant women.

If patients with diabetes have already used alicline fumarate to reduce blood pressure (unless other antihypertensive treatments fail and blood pressure control is very unsatisfactory).

11、 Drug interactions

Prohibition of combined use (prohibition of combination): When diabetes patients use alicline fumarate in combination, they must be strictly contraindicated (unless other treatments still have poor pressure control).

Be cautious and use (precautions):

Potassium salt supplements and potassium sparing diuretics may increase the risk of elevated blood potassium levels.

Sodium diuretics (such as furosemide) can cause initial acute hypotensive reactions; Start with a low dose and slowly increase the dosage.

The combination of lithium preparations may cause lithium poisoning.

The combination of similar ARBs or ACEIs drugs increases the risk of hyperkalemia and hypotension.

Non steroidal anti-inflammatory drugs may weaken the blood pressure lowering effect of this product and cause renal function deterioration.

Bioequivalence: Data shows that Omeprazole orally disintegrating tablets have similar bioequivalence to traditional tablets and are not affected by high-fat diets.

12、 Storage method

Packaging form: PTP packaging (with desiccant) or plastic bottles (with desiccant inserted) to prevent moisture.

Storage conditions: The medicine should be stored at room temperature to prevent moisture.

Attention before use: Keep moisture-proof even after opening the packaging or bottle.

13、 Manufacturer

Daiichi Sankyo Company, Limited.

Olmetecinformation