Compound Topiramine Eye Drops are a topical medication for compound ophthalmology, mainly containing two active ingredients: Topiramine and Norepinephrine Hydrochloride. They belong to a compound preparation of anticholinergic drugs and α 1-adrenergic receptor agonists.

1、 Drug name

Compound Topiramine Ophthalmic Solution.

2、 Indications

Used for dilating pupils and adjusting paralysis, suitable for situations requiring fundus examination or refractive examination.

3、 Specifications and characteristics

1. Specification: Each vial contains a combination of topiramine and epinephrine.

2. Appearance: Colorless to slightly yellow clear liquid.

4、 Main components

1. Tropicamide.

2. Phenylephrine Hydrochloride.

5、 Usage and dosage

1. Conventional usage: 1 drop each time, 2-3 times a day, the specific frequency needs to be adjusted according to the examination requirements.

2. Special usage: If you need a strong dilating effect, you can apply 1-2 drops every few minutes before the examination.

3. Attention: After medication, it is necessary to press the nasolacrimal duct for a few minutes to reduce systemic absorption.

6、 Dose adjustment

1. Elderly patients, those with liver dysfunction, or those who are sensitive to drugs should reduce their dosage as appropriate.

2. Children's medication should be adjusted in dosage under the guidance of a doctor.

7、 Medication precautions

1. Before and after meals: There are no special requirements, but there may be blurred vision after medication. It is recommended to avoid driving or operating precision instruments.

2. Leakage: If there is a leakage, there is no need to replenish it, just use it according to the next scheduled time.

3. Vomiting: If severe vomiting or discomfort occurs after medication, the medication should be stopped immediately and medical attention sought.

4. Other: After use, close your eyes and press the inner corner of your eye for 1-2 minutes to avoid systemic reactions caused by drug absorption through the nasolacrimal duct.

8、 Medication for special populations

1. Pregnant and lactating women: Use only when it is clearly necessary and the risk needs to be evaluated by a doctor.

2. Children: Use under the guidance of a doctor, dosage may need to be adjusted.

3. Elderly people: may be more sensitive to medication, it is recommended to start with low doses.

4. Glaucoma patients: Use with caution, especially contraindicated for patients with angle closure glaucoma.

9、 Adverse reactions

1. Common: Transient blurred vision, eye irritation, photophobia.

2. Rare: Elevated intraocular pressure, allergic reactions (such as eyelid redness and swelling), increased heart rate, headache.

3. Serious adverse reactions: acute onset of angle closure glaucoma, cardiovascular system reactions (such as hypertension, arrhythmia).

10、 Contraindications

1. Do not use for individuals allergic to topiramine, norepinephrine, or any other ingredients.

2. Patients with angle closure glaucoma are prohibited from using it.

3. Patients with severe cardiovascular diseases (such as severe hypertension and coronary heart disease) are prohibited from using it.

4. Hyperthyroidism patients should use with caution or avoid use.

11、 Drug interactions

1. Combined use with monoamine oxidase inhibitors (MAOIs) may enhance the pressor effect of norepinephrine, leading to hypertensive crisis.

2. Combined use with tricyclic antidepressants and anticholinergic drugs may enhance mydriasis and regulate paralysis effects.

3. When used with other eye drops, at least 5-10 minutes should be allowed between them.

12、 Storage method

1. Avoid light, seal, and store in a cool place (usually recommended 2-8 ° C).

2. After opening, it should be used within the prescribed period (usually 4 weeks) to avoid contamination.

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